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Islet Award Initiative (IAI) Awardees

The following investigators new to human islet research received free islets via the Islet Award Initiative to support their projects:

Type Name Institution Study Title Approval Date Completion Date
IAIAmit ChoudharyBroad Institute, Harvard Medical School, Brigham and Women's HospitalDevelopment of Small Molcule-Based Methods for Targeted Cargo Delivery to Beta Cells8/6/187/2/22
IAIPamela Itkin-AnsariUniversity of California, San DiegoProinsulin Interactions that Promote Proper Protein Folding in Type I Diabetes6/4/183/31/21
IAIMichael A. KalwatUT SouthwesternDefine mechanisms of action of islet beta-cell glucose-response modulators11/16/1810/31/20
IAIAmelia LinnemannIndiana University School of MedicineReal-time in vivo analysis of islet autophagy11/16/1812/30/25
IAIKathrin MaedlerUniversity of BremenPHLPPing the ß-cell- a new target for Type 2 Diabetes8/2/1812/31/19
IAIEdward PhelpsUniversity of FloridaA Human Islet Neurotransmitter Atlas8/2/1812/31/25
IAIVincent PoitoutUniversity of MontréalSingle-cell RNA-seq to investigate oleate-induced human beta-cell proliferation11/16/186/30/19
IAIMihaela Stefan-LifshitzAlbert Einstein College of MedicineEnvironmental toxicant exposures as determinants of type 1 diabetes8/2/188/1/21
IAIJeffery S. TessemBrigham Young UniversityExploring mechanisms by which beta cell heterogeneity effects beta cell proliferation6/4/1812/31/20
IAIPing WangMichigan State UniversityMagnetic particle imaging of transplanted islets in type 1 diabetes animal models11/16/186/30/21
IAIRonadip R. BanerjeeJohns Hopkins School of MedicineProlactin receptor signaling regulation of human beta-cell proliferation and function3/25/1912/31/23
IAIVincenzino CirulliUniversity of WashingtonRegulation of human islet cell expansion by cell adhesion signaling3/25/1912/31/22
IAIBethany CummingsUC DavisA new single cell RNA-sequencing technique for the study of islet GLP-1 receptor signaling5/28/196/30/24
IAIE. Danielle DeanVanderbilt University Medical CenterNutrient regulation of islet cell function and proliferation10/15/1912/29/23
IAIFeyza EnginUniversity of Wisconsin, MadisonIdentifying the mechanisms of stress-induced ß-cell dedifferentiation in prevention of T1D10/15/197/31/23
IAIGareth LimCRCHUMAssessing the roles of 14-3-3 proteins in human beta-cells10/15/1910/14/21
IAIJames LoWeill Cornell Medical CollegeAlternative Complement Pathway Regulation of Beta Cells3/25/193/25/21
IAIXuelin LouMedical College of WisconsinEndocytosis in human beta cells3/25/1912/31/22
IAIYue J. WangFlorida State UniversitySingle-cell transcriptomics of proliferating beta and alpha cells3/25/194/1/22
IAILing-gang WuNINDSVisualization of Membrane Pore, fusion and fission in live pancreatic beta cells5/28/1912/31/21
IAIEsma S. YolcuUniversity of MissouriTargeted delivery of immunomodulatory biologics for induction of immune privilege to allogeneic pancreatic islet grafts10/15/1912/31/22
IAIJason BiniYale UniversityValidation of 11C-(+)-PHNO as an in vivo biomarker for beta cell mass3/4/2012/31/22
IAIErcument DiriceNew York Medical CollegeIdentifying beta-cell subpopulations that resist immune destruction in T1D9/17/2012/31/25
IAIKaren ForbesUniversity of LeedsMaternal pancreatic-derived extracellular vesicles and their miRNA cargo as novel regulators of placental and fetal growth in pregnancies complicated by maternal diabetes6/25/207/1/24
IAIJing HughesWashington UniversityPrimary Cilia in Islet Paracrine Regulation3/4/2011/30/23
IAIKok Lim KuaIndiana University School of MedicineReg3g-mediated heparan sulfate glycans as a drug-sensitive target mediating islet dysfunction in offspring of obese mothers9/17/2012/31/25
IAIHongxia RenIndiana UniversityInvestigating the Molecular Mechanisms Underlying How GPR17 Intestinal Deficiency Promotes Pancreatic Islet Insulin Secretion3/4/209/30/22
IAIZong WeiMayo Clinic ArizonaVitamin D and chromatin dynamics in human islet dysfunction6/22/205/31/23
IAIEiji YoshiharaLundquist Institute at Harbor-UCLA Medical CenterAnalysis of human islet organogenesis6/22/203/31/22
IAIMatthew PoyJohns Hopkins All Children’s HospitalRole of Islet CADM1 in Intercellular Contact during Type 1 Diabetes Pathogenesis4/27/214/30/23
IAITaylor TrioloUniversity of Colorado School of MedicineElucidating the role of high-risk diabetes genes on human beta cell function in health and disease4/27/216/30/23
IAIYi YeAlbert Einstein College of MedicineTitle: Investigating the functional roles of PGM1 in beta cells during islet autoimmune development4/27/214/27/23
IAIEmilyn AlejandroUniversity of MinnesotaExploring Islet O-GlcNAcylation in Hyperinsulinemia-Induced Obesity 7/19/227/19/24
IAIJuan R. AlvarezUNIVERSITY OF PENNSYLVANIARegulatory Architecture of the Human Pancreatic Islet Clock4/20/2212/1/24
IAIJustin AnnesStanford Medical SchoolPressure Driven Insulin Dosing Improves Glycemic Control and Islet Viability 7/19/2212/31/25
IAIDana Avrahami-TzfatiHebrew University Drivers and consequences of ß-cell senescence in human islets7/19/2212/31/24
IAILynne ColuccioBoston University School of MedicineRole of myosin-I in insulin granule biogenesis4/20/223/14/23
IAIFeyza EnginUniversity of Wisconsin, MadisonIdentifying adaptive plasticity of human ß-cells under chronic and episodic stress conditions7/19/229/30/25
IAILeonardo FerreiraMedical University of South CarolinaEngineering human regulatory T cells to protect human pancreatic islets from immune attack4/20/2212/31/24
IAIHyowon Hugh LeePurdue UniversityAdvanced 3D microphysiological system integrated with electrochemical sensors for rapid evaluation of dynamic pancreatic ß-cell function7/19/223/31/23
IAIAida Martinez-SanchezImperial College LondonThe role of mitochondrial fission process 1 (Mtfp1) in human pancreatic ß- cells4/20/221/1/25
IAIMatthew J. MerrinsUniversity of Wisconsin-MadisonAmino acid regulation of human alpha-cells 7/19/226/15/24
IAIIbrahim T. OzbolatPenn StateHigh-throughput Bioprinting of Islets for Fabrication of Pancreatic Devices for Type 1 Diabetes4/20/222/29/24
IAISasanka RamanadhamUniversity of AlabamaAssessing intercellular signaling delivered by extracellular vesicles (EVs) released by human islet beta-cells7/19/2212/31/23
IAICarsten SchultzOHSUThe pancreatic islet in a nutshell - how intraislet communication influences hormone secretion4/20/2210/31/24
IAIPeter ThompsonUniversity of ManitobaMechanisms and targeting of senescent human beta cells in Type 1 Diabetes4/20/229/30/24
IAIJames FrankOHSU - Oregon Health & Science UniversityIlluminating the mechanisms through which cannabinoid receptors regulate human pancreatic islet calcium-oscillations with photochemical tools8/1/236/30/25
IAIKarla F. LeavensChildren's Hospital of PhiladelphiaThe role of hypoxia in beta cell identity and metabolism8/1/238/31/25
IAIEd StanleyMurdoch Children's Research InstituteIdentification of novel cell surface markers of pancreatic endocrine cells8/14/2312/31/26
IAIRomina BevacquaIcahn School of Medicine at Mount SinaiNovel Genomic Approaches For Prevention And Reversal of Diabetes8/27/246/30/26
IAILauryn CholevaIcahn School of Medicine at Mount SinaiExploring the Function of p57KIP2 in Diseases of The Human Pancreatic Beta Cell8/27/246/13/25
IAIKathryn CoateVanderbilt UniversityPancreatic islet alpha cell response to insulin resistance and type 2 diabetes8/27/249/30/26
IAIYingfeng DengCity of HopeUridine potentiated insulin secretion from pancreatic islet ß cells8/27/247/31/25
IAIAngela LombardiAlbert Einstein College of MedicineExogenous ketones and type 1 diabetes8/27/247/31/25
IAISteven J. MillershipImperial College LondonHarnessing epidrugs to functionally enhance in vitro-derived islets8/27/249/1/27
IAIJordan J. WrightVanderbilt University Medical CenterIn vivo mechanisms of amyloid-induced pancreatic islet dysfunction in type 2 diabetes8/27/246/30/28
IAIHan ZhuThe University of Colorado Anschutz Medical CampusRNA epigenetic regulation of metabolic status of human ß-cells.8/27/2412/31/25
IAIAkos A. GerencserBuck Institute for Research on AgingBeta-cell mitochondrial energy metabolism in type 2 diabetes6/10/2512/31/28