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Our History

July, 2016

First HIPP Shipments

July, 2016

Since July of 2016, the Human Islet Phenotyping Program has been providing post-shipment data on islet shipments to investigators. This confirms the integrity of the islets post-shipment and provides purity, viability and functional data that will be available to investigators through the IIDP website.

October, 2012

Current IIDP Grant Selection of Six Isolation Centers

October, 2012

In 2009, the IIDP issued RFAs for islet isolation centers to serve as IIDP Centers providing high quality human islets to the diabetes research community. After careful review of islet isolation center production and capabilities as well as geographic location, the IIDP selected 6 centers to participate in the program. In 2012, the grant was renewed and the same 6 centers have remained as the current islet isolation centers affiliated with the IIDP.

January, 2011

Pilot Program Initiated

January, 2011

In an effort to support investigators new to human islet research, investigators with bridge funding, and investigators wishing to pursue small pilots prior to submitting a grant, the IIDP initiated a Pilot Program to provide investigators with up to 250,000 IEQs without the need to pay a subscription fee. Multiple investigators have used this option to date and over 85% have succeeded in acquiring funding post Pilot Program.

April, 2010

First CIT Islet Broadcast

April, 2010

The Clinical Islet Transplant (CIT) Program supported by NIDDK in 2010 requested that islets isolated but not used for transplant from the CIT program be offered to the research community so that this precious resource was not wasted. IIDP added all active CIT centers as islet isolation centers and distributed islets from the CIT.

August, 2009

Conversion of ICR to IIDP

August, 2009

In 2009, NIH issued an RFA for a contract to supply human islets to the research community. City of Hope, under the guidance of Dr. Joyce Niland, won the award having managed the previous grant supported by National Center for Research Resources (NCRR). The IIDP has been serving the needs of the islet research community since 2009.

April, 2008

Start of JDRF Islet Distribution Program

April, 2008

In 2008, the JDRF suggested that their islet isolation Centers distribute islets to JDRF investigators through the existing ICR web-based infrastructure utilizing the MAID algorithm. The ICR incorporated these Centers into its distribution program. Any islets not distributed to JDRF investigators were subsequently distributed to ICR investigators. This served as a way to maximize the use of isolated human islets for research and grew the ICR’s investigator base.

March, 2007

1st Islet Broadcast via Matching Algorithm for Islet Distribution(MAID)

March, 2007

In order to ensure that all approved investigators were treated fairly in the distribution of human islets by the ICR, the ICR-ABCC developed an algorithm that matches the investigators’ requests for islets and donor criteria with the islets available for distribution. This algorithm ensures a fair and equitable distribution of human islets to the research community based on investigator need.

February, 2004

Start of ICR Basic Science Distributions

February, 2004

In 2004, the ICR who had previously distributed human islets for clinical transplant, began distributing human islets for research. This distribution occurred by a manual method of calling investigators to determine if the islets available could be placed. From 2004 to 2007, the ICR worked on developing an automated system for islet distribution and in 2007 succeeded in distributing islets using the MAID algorithm.

September, 2002

Administrative and Bioinformatics Coordinating Center

September, 2002

Shortly after the creation of the ICR, the National Center for Research Resources (NCRR) commissioned the Administrative and Bioinformatics Coordinating Center (ABCC) for the administration and data support of the ICR. City of Hope, under the leadership of Dr. Joyce Niland, was granted this award and maintained the administrative and biostatistical management role of the ICR until the program's completion and transition into its new iteration as the Integrated Islet Distribution Program (IIDP) in 2009. As the ICR-ABCC, City of Hope provided web development, data collection, statistical analysis, scientific study facilitation, and islet distribution infrastructure and logistical support.

2001

Islet Cell Resource Project Launched

2001

The Islet Cell Resource Centers (ICRs), were funded by the National Center for Research Resources and the National Institute of Diabetes and Digestive and Kidney Diseases, components of the National Institutes of Health, Department of Health and Human Services from September, 2001 through July, 2009, and comprised an interactive group of 10 academic laboratories charged with three major goals: 1) to provide pancreatic islets of cGMP-quality to eligible investigators for use in FDA-approved, IRB-approved transplantation protocols; 2) to optimize the harvest, purification, function, storage, and shipment of islets while developing tests that characterized the quality and predicted the effectiveness of islets transplanted into patients with diabetes mellitus; and 3) to provide pancreatic islets for basic science studies.