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IIDP investigators using human islets or other resources from the IIDP and who publish their research are required to cite the IIDP (previously known as the Islet Cell Resource Center Consortium, or ICR) and are encouraged to submit these publications to the IIDP Coordinating Center (cswanson@coh.org or IIDP-email@coh.org).

The following type of acknowledgement, which includes the IIDP NIH grant #, should be documented in all publications where IIDP human Islets or other resources were used:

Human pancreatic islets and/or other resources were provided by the NIDDK-funded Integrated Islet Distribution Program (IIDP) (RRID:SCR _014387) at City of Hope, NIH Grant # U24DK098085.

If you obtained islets or other resources via the IIDP’s Islet Award Initiative (IAI), please state the following:

Human pancreatic islets and/or other resources were provided by the NIDDK-funded Integrated Islet Distribution Program (IIDP) (RRID:SCR _014387) at City of Hope, NIH Grant # U24DK098085 and the JDRF-funded IIDP Islet Award Initiative.

Please refer to the IIDP Publications and Presentations Policy for complete instructions on citing your research.

 

PUBLICATIONS BY INVESTIGATORS USING HUMAN ISLETS (885)

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  • Publications by the IIDP Coordinating Center
  • Published SOPs by the IIDP Coordinating Center
  • Publications of Interest
2023 (26)
Cha J, Tong X, Walker EM, Dahan T, Cochrane VA, Ashe S, Russell R, Osipovich AB, Mawla AM, Guo M, Liu JH, Loyd ZA, Huising MO, Magnuson MA, Hebrok M, Dor Y, Stein R: Species-specific roles for the MAFA and MAFB transcription factors in regulating islet beta cell identity. JCI Insight, 2023 Aug 22, 8(16).
Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C: SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells. Diabetologia, 2023 Aug 4, 75:101775.
Knuth ER, Foster HR, Jin E, Merrins MJ: Leucine suppresses glucagon secretion from pancreatic islets by directly modulating alpha-cell cAMP. bioRxiv, 2023 Aug 16.
St Clair JR, Westacott MJ, Miranda J, Farnsworth NL, Kravets V, Schleicher WE, Dwulet JM, Levitt CH, Heintz A, Ludin NWF, Benninger RKP: Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction. J Physiol, 2023 Aug 14.
Thomaidou S, Munoz Garcia A, de Lange S, Gan J, van der Slik AR, Hoeben RC, Roep BO, Carlotti F, Zaldumbide A: IFNɣ but not IFNalpha increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity. Diabetologia, 2023 Aug 15.
Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN: Excess pancreatic elastase alters acinar-beta cell communication by impairing the mechano-signaling and the PAR2 pathways. Cell Metab, 2023 Jul 11, 35(7):1242-1260 e1249.
Yeh YT, Sona C, Yan X, Li Y, Pathak A, McDermott MI, Xie Z, Liu L, Arunagiri A, Wang Y, Cazenave-Gassiot A, Ghosh A, von Meyenn F, Kumarasamy S, Najjar SM, Jia S, Wenk MR, Traynor-Kaplan A, Arvan P, Barg S, Bankaitis VA, Poy MN: Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction. Nat Commun, 2023 Jul 17, 14(1):4250.
Brennecke BR, Yang U, Liu S, Ilerisoy FS, Ilerisoy BN, Joglekar A, Kim LB, Peachee SJ, Richtsmeier SL, Stephens SB, Sander EA, Strack S, Moninger TO, Ankrum JA, Imai Y: Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy. Front Endocrinol (Lausanne), 2023, 14:1187216
Chai S, Wakefield L, Norgard M, Li B, Enicks D, Marks DL, Grompe M: Strong ubiquitous micro-promoters for recombinant adeno-associated viral vectors. Mol Ther Methods Clin Dev, 2023 Jun 8, 29:504-512.
El K, Douros JD, Willard FS, Novikoff A, Sargsyan A, Perez-Tilve D, Wainscott DB, Yang B, Chen A, Wothe D, Coupland C, Tschop MH, Finan B, D'Alessio DA, Sloop KW, Muller TD, Campbell JE: The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets. Nat Metab, 2023 Jun, 5(6):945-954.
Syed F, Krishnan P, Chang G, Langlais SR, Hati S, Yamada K, Lam AK, Talware S, Liu X, Sardar R, Liu J, Mirmira RG, Evans-Molina C: Title: beta Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk. bioRxiv, 2023 Jun 15
Lacombe J, Guo K, Bonneau J, Faubert D, Gioanni F, Vivoli A, Muir SM, Hezzaz S, Poitout V, Ferron M: Vitamin K-dependent carboxylation regulates Ca(2+) flux and adaptation to metabolic stress in beta cells. Cell Rep, 2023 May 30, 42(5):112500.
Polino AJ, Sviben S, Melena I, Piston DW, Hughes JW: Scanning electron microscopy of human islet cilia. Proc Natl Acad Sci U S A, 2023 May 30, 120(22):e2302624120.
van Tienhoven R, Kracht MJL, van der Slik AR, Thomaidou S, Wolters AHG, Giepmans BNG, Riojas JPR, Nelson MS, Carlotti F, de Koning EJP, Hoeben RC, Zaldumbide A, Roep BO: Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells. Diabetologia, 2023 May, 66(5):884-896.
Xu W, Qadir MMF, Nasteska D, Mota de Sa P, Gorvin CM, Blandino-Rosano M, Evans CR, Ho T, Potapenko E, Veluthakal R, Ashford FB, Bitsi S, Fan J, Bhondeley M, Song K, Sure VN, Sakamuri S, Schiffer L, Beatty W, Wyatt R, Frigo DE, Liu X, Katakam PV, Arlt W, Buck J, Levin LR, Hu T, Kolls J, Burant CF, Tomas A, Merrins MJ, Thurmond DC, Bernal-Mizrachi E, Hodson DJ, Mauvais-Jarvis F: Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic beta cells. Cell Rep, 2023 May 30, 42(5):112529./td>
Erdem N, Chen KT, Qi M, Zhao Y, Wu X, Garcia I, Ku HT, Montero E, Al-Abdullah IH, Kandeel F, Roep BO, Isenberg JS: Thrombospondin-1, CD47, and SIRPalpha display cell-specific molecular signatures in human islets and pancreata. Am J Physiol Endocrinol Metab, 2023 Apr 1, 324(4):E347-E357.
Ho T, Potapenko E, Davis DB, Merrins MJ: A plasma membrane-associated glycolytic metabolon is functionally coupled to K(ATP) channels in pancreatic alpha and beta cells from humans and mice. Cell Rep, 2023 Apr 13, 42(4):112394.
Kalwat MA, Rodrigues-Dos-Santos K, Binns DD, Wei S, Zhou A, Evans MR, Posner BA, Roth MG, Cobb MH: Small molecule glucagon release inhibitors with activity in human islets. Front Endocrinol (Lausanne), 2023 Apr 19, 14:1114799.
Rubio-Navarro A, Gomez-Banoy N, Stoll L, Dundar F, Mawla AM, Ma L, Cortada E, Zumbo P, Li A, Reiterer M, Montoya-Oviedo N, Homan EA, Imai N, Gilani A, Liu C, Naji A, Yang B, Chong ACN, Cohen DE, Chen S, Cao J, Pitt GS, Huising MO, Betel D, Lo JC: A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nat Cell Biol, 2023 Apr, 25(4):565-578.
Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schule R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M: Nutrient regulation of the islet epigenome controls adaptive insulin secretion. J Clin Invest, 2023 Apr 17, 133(8).
De Jesus DF, Zhang Z, Brown NK, Li X, Gaffrey MJ, Kahraman S, Wei J, Hu J, Basile G, Xiao L, Rana TM, Mathews C, Powers AC, Atkinson MA, Eizirik DL, Dhe-Paganon S, Parent AV, Qian WJ, He C, Kulkarni RN: Redox Regulation of m (6) A Methyltransferase METTL3 in Human beta-cells Controls the Innate Immune Response in Type 1 Diabetes. bioRxiv, 2023 Feb 16.
Dong G, Adak S, Spyropoulos G, Zhang Q, Feng C, Yin L, Speck SL, Shyr Z, Morikawa S, Kitamura RA, Kathayat RS, Dickinson BC, Ng XW, Piston DW, Urano F, Remedi MS, Wei X, Semenkovich CF: Palmitoylation couples insulin hypersecretion with beta cell failure in diabetes. Cell Metab, 2023 Feb 7, 35(2):332-344 e337.
Polino AJ, Sviben S, Melena I, Piston DW, Hughes J: Scanning electron microscopy of human islet cilia. bioRxiv, 2023 Feb 15.
Tremmel DM, Mikat AE, Gupta S, Mitchell SA, Curran AM, Menadue JA, Odorico JS, Sackett SD: Validating expression of beta cell maturation-associated genes in human pancreas development. Front Cell Dev Biol, 2023 Feb 28, 11:1103719.
Liu QR, Zhu M, Chen Q, Mustapic M, Kapogiannis D, Egan JM: Novel Hominid-Specific IAPP Isoforms: Potential Biomarkers of Early Alzheimer's Disease and Inhibitors of Amyloid Formation. Biomolecules, 2023 Jan 13, 13(1).
Peng G, Mosleh E, Yuhas A, Katada K, Cherry C, Golson ML: FOXM1 acts sexually dimorphically to regulate functional beta-cell mass. bioRxiv, 2023 Jan 12.
2022 (40)
Kato H, Miwa T, Quijano J, Medrano L, Ortiz J, Desantis A, Omori K, Wada A, Tatsukoshi K, Kandeel F, Mullen Y, Ku HT, Komatsu H: Microwell culture platform maintains viability and mass of human pancreatic islets. Front Endocrinol (Lausanne), 2022 Dec 6 Epub, 13:1015063.
Katz LS, Argmann C, Lambertini L, Scott DK: T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased beta-cell proliferation. Mol Metab, 2022 Dec, 66:101646.
Castell AL, Goubault C, Ethier M, Fergusson G, Tremblay C, Baltz M, Dal Soglio D, Ghislain J, Poitout V: beta Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood. JCI Insight, 2022 Nov 8, 7(21).
Tran DT, Pottekat A, Lee K, Raghunathan M, Loguercio S, Mir SA, Paton AW, Paton JC, Arvan P, Kaufman RJ, Itkin-Ansari P: Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets. J Clin Endocrinol Metab, 2022 Nov 23, 107(11):3100-3110.
Brawerman G, Ntranos V, Thompson PJ: Alpha cell dysfunction in type 1 diabetes is independent of a senescence program. Front Endocrinol (Lausanne), 2022 Oct 25, 13:932516.
Dickerson MT, Dadi PK, Zaborska KE, Nakhe AY, Schaub CM, Dobson JR, Wright NM, Lynch JC, Scott CF, Robinson LD, Jacobson DA: G(i/o) protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na(+)/K(+) ATPase activation. Nat Commun, 2022 Oct 29, 13(1):6461.
Li ZA, Cho JH, Woodhams LG, Hughes JW: Fluorescence imaging of beta cell primary cilia. Front Endocrinol (Lausanne), 2022 Oct, 13:1004136.
Yong HJ, Toledo MP, Nowakowski RS, Wang YJ: Sex Differences in the Molecular Programs of Pancreatic Cells Contribute to the Differential Risks of Type 2 Diabetes. Endocrinology, 2022 Oct 11, 163(11).
Cho JH, Li ZA, Zhu L, Muegge BD, Roseman HF, Lee EY, Utterback T, Woodhams LG, Bayly PV, Hughes JW: Islet primary cilia motility controls insulin secretion. Sci Adv, 2022 Sep 23, 8(38):eabq8486.
Perdigoto AL, Deng S, Du KC, Kuchroo M, Burkhardt DB, Tong A, Israel G, Robert ME, Weisberg SP, Kirkiles-Smith N, Stamatouli AM, Kluger HM, Quandt Z, Young A, Yang ML, Mamula MJ, Pober JS, Anderson MS, Krishnaswamy S, Herold KC: Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes. JCI Insight, 2022 Sep 8, 7(17).
Zaborska KE, Jordan KL, Thorson AS, Dadi PK, Schaub CM, Nakhe AY, Dickerson MT, Lynch JC, Weiss AJ, Dobson JR, Jacobson DA: Liraglutide increases islet Ca(2+) oscillation frequency and insulin secretion by activating hyperpolarization-activated cyclic nucleotide-gated channels. Diabetes Obes Metab, 2022 Sep, 24(9):1741-1752.
Brawerman G, Pipella J, Thompson PJ: DNA damage to beta cells in culture recapitulates features of senescent beta cells that accumulate in type 1 diabetes. Mol Metab, 2022 Aug, 62:101524.
Casteels T, Bajew S, Reinis J, Enders L, Schuster M, Fontaine F, Muller AC, Wagner BK, Bock C, Kubicek S: SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression. Cell Rep, 2022 Aug 30, 40(9):111288.
Gloyn AL, Ibberson M, Marchetti P, Powers AC, Rorsman P, Sander M, Solimena M: Every islet matters: improving the impact of human islet research. Nat Metab, 2022 Aug, 4(8):970-977.
Lee CJ, Schnieders JH, Rubakhin SS, Patel AV, Liu C, Naji A, Sweedler JV: d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans. Metabolites, 2022 Aug 27, 12(9).
Pfeiffer SEM, Quesada-Masachs E, McArdle S, Zilberman S, Yesildag B, Mikulski Z, von Herrath M: Effect of IL4 and IL10 on a human in vitro type 1 diabetes model. Clin Immunol, 2022 Aug, 241:109076.
Wang P, Karakose E, Argmann C, Wang H, Balev M, Brody RI, Rivas HG, Liu X, Wood O, Liu H, Choleva L, Hasson D, Bernstein E, Paulo JA, Scott DK, Lambertini L, DeCaprio JA, Stewart AF: Disrupting the DREAM complex enables proliferation of adult human pancreatic beta cells. J Clin Invest, 2022 Aug 1, 132(15).
Holter MM, Phuong DJ, Lee I, Saikia M, Weikert L, Fountain S, Anderson ET, Fu Q, Zhang S, Sloop KW, Cummings BP: 14-3-3-zeta mediates GLP-1 receptor agonist action to alter alpha cell proglucagon processing. Sci Adv, 2022 Jul 22, 8(29):eabn3773.
Rodrigues-Dos-Santos K, Roy G, Binns DD, Grzemska MG, Barella LF, Armoo F, McCoy MK, Huynh AV, Yang JZ, Posner BA, Cobb MH, Kalwat MA: Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function. Endocrinology, 2022 Jul 1, 163(7).
De Toni T, Stock AA, Devaux F, Gonzalez GC, Nunez K, Rubanich JC, Safley SA, Weber CJ, Ziebarth NM, Buchwald P, Tomei AA: Parallel Evaluation of Polyethylene Glycol Conformal Coating and Alginate Microencapsulation as Immunoisolation Strategies for Pancreatic Islet Transplantation. Front Bioeng Biotechnol, 2022 Jun 3, 10:886483.
Doliba NM, Rozo AV, Roman J, Qin W, Traum D, Gao L, Liu J, Manduchi E, Liu C, Golson ML, Vahedi G, Naji A, Matschinsky FM, Atkinson MA, Powers AC, Brissova M, Kaestner KH, Stoffers DA, Consortium H: alpha Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals. J Clin Invest, 2022 Jun 1, 132(11).
Kim HT, Desouza AH, Umhoefer H, Han J, Anzia L, Sacotte SJ, Williams RA, Blumer JT, Bartosiak JT, Fontaine DA, Baan M, Kibbe CR, Davis DB: Cholecystokinin attenuates beta-cell apoptosis in both mouse and human islets. Transl Res, 2022 May, 243:1-13.
MacMillan HJ, Kong Y, Calvo-Roitberg E, Alonso LC, Pai AA: High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets. Sci Rep, 2022 May 11, 12(1):7745.
Salib A, Cayabyab F, Yoshihara E: Stem Cell-Derived Islets for Type 2 Diabetes. Int J Mol Sci, 2022 May 4, 23(9).
Tremmel DM, Sackett SD, Feeney AK, Mitchell SA, Schaid MD, Polyak E, Chlebeck PJ, Gupta S, Kimple ME, Fernandez LA, Odorico JS: A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment. Sci Rep, 2022 May 3, 12(1):7188.
Xu G, Chen J, Jo S, Grayson TB, Ramanadham S, Koizumi A, Germain-Lee EL, Lee SJ, Shalev A: Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and Diabetes. Endocrinology, 2022 May 1, 163(5).
Darden CM, Vasu S, Mattke J, Liu Y, Rhodes CJ, Naziruddin B, Lawrence MC: Calcineurin/NFATc2 and PI3K/AKT signaling maintains beta-cell identity and function during metabolic and inflammatory stress. iScience, 2022 Apr 15, 25(4):104125.
Fuselier T, Mota de Sa P, Qadir MMF, Xu B, Allard C, Meyers MM, Tiano JP, Yang BS, Gelfanov V, Lindsey SH, Dimarchi RD, Mauvais-Jarvis F: Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes. Cell Reports Medicine, 2022 Apr 4, 3(4):100598.
Mugabo Y, Zhao C, Tan JJ, Ghosh A, Campbell SA, Fadzeyeva E, Pare F, Pan SS, Galipeau M, Ast J, Broichhagen J, Hodson DJ, Mulvihill EE, Petropoulos S, Lim GE: 14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells. JCI Insight, 2022 Apr 22, 7(8).
van Gurp L, Fodoulian L, Oropeza D, Furuyama K, Bru-Tari E, Vu AN, Kaddis JS, Rodriguez I, Thorel F, Herrera PL: Generation of human islet cell type-specific identity genesets. Nat Commun, 2022 Apr 19, 13(1):2020.
Yoshihara E: Adapting Physiology in Functional Human Islet Organogenesis. Front Cell Dev Biol, 2022 Apr, 10:854604.
Bartolome A, Suda N, Yu J, Zhu C, Son J, Ding H, Califano A, Accili D, Pajvani UB: Notch-mediated Ephrin signaling disrupts islet architecture and beta cell function. JCI Insight, 2022 Mar 22, 7(6).
Evans RM, Wei Z: Interorgan crosstalk in pancreatic islet function and pathology. FEBS Lett, 2022 Mar, 596(5):607-619.
Garvey RW, Lacivita E, Niso M, Duszynska B, Harris PE, Leopoldo M: Design, Synthesis, and Characterization of a Novel Fluoroprobe for Live Human Islet Cell Imaging of Serotonin 5-HT1A Receptor. ChemMedChem, 2022 Mar 14:e202100759.
Tong X, Liu S, Stein R, Imai Y: Lipid Droplets' Role in the Regulation of beta-Cell Function and beta-Cell Demise in Type 2 Diabetes. Endocrinology, 2022 Mar 1, 163(3).
Xu G, Grimes TD, Grayson TB, Chen J, Thielen LA, Tse HM, Li P, Kanke M, Lin TT, Schepmoes AA, Swensen AC, Petyuk VA, Ovalle F, Sethupathy P, Qian WJ, Shalev A: Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes. Nat Commun, 2022 Mar 3, 13(1):1159.
Baumel-Alterzon S, Katz LS, Brill G, Jean-Pierre C, Li Y, Tse I, Biswal S, Garcia-Ocana A, Scott DK: Nrf2 Regulates beta-cell Mass by Suppressing beta-Cell Death and Promoting beta-Cell Proliferation. Diabetes, 2022 Feb 22.
Quesada-Masachs E, Zilberman S, Rajendran S, Chu T, McArdle S, Kiosses WB, Lee JM, Yesildag B, Benkahla MA, Pawlowska A, Graef M, Pfeiffer S, Mikulski Z, von Herrath M: Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes. Diabetologia, 2022 Feb, 65(2):387-401.
Kahraman S, Dirice E, Basile G, Diegisser D, Alam J, Johansson BB, Gupta MK, Hu J, Huang L, Soh CL, Huangfu D, Muthuswamy SK, Raeder H, Molven A, Kulkarni RN: Abnormal exocrine-endocrine cell cross-talk promotes beta-cell dysfunction and loss in MODY8. Nat Metab, 2022 Jan, 4(1):76-89.
Cheung R, Pizza G, Chabosseau P, Rolando D, Tomas A, Burgoyne T, Wu Z, Salowka A, Thapa A, Macklin A, Cao Y, Nguyen-Tu MS, Dickerson MT, Jacobson DA, Marchetti P, Shapiro J, Piemonti L, de Koning E, Leclerc I, Bouzakri K, Sakamoto K, Smith DM, Rutter GA, Martinez-Sanchez A: Glucose-Dependent miR-125b Is a Negative Regulator of beta-Cell Function. Diabetes, 2022 Jul 1, 71(7):1525-1545.
2021 (46)
Armitage LH, Stimpson SE, Santostefano KE, Sui L, Ogundare S, Newby BN, Castro-Gutierrez R, Huber MK, Taylor JP, Sharma P, Radichev IA, Perry DJ, Fredette NC, Savinov AY, Wallet MA, Terada N, Brusko TM, Russ HA, Chen J, Egli D, Mathews CE: Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes. Front Endocrinol (Lausanne), 2021 Dec 04, 12:737276.
Son J, Ding H, Farb TB, Efanov AM, Sun J, Gore JL, Syed SK, Lei Z, Wang Q, Accili D, Califano A: BACH2 inhibition reverses beta cell failure in type 2 diabetes models. J Clin Invest, 2021 Dec 15, 131(24).
Docherty FM, Riemondy KA, Castro-Gutierrez R, Dwulet JM, Shilleh AH, Hansen MS, Williams SPM, Armitage LH, Santostefano KE, Wallet MA, Mathews CE, Triolo TM, Benninger RKP, Russ HA: ENTPD3 Marks Mature Stem Cell-Derived beta-Cells Formed by Self-Aggregation In Vitro. Diabetes, 2021 Nov, 70(11):2554-2567.
Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN: Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep, 2021 Nov 23, 37(8):110037.
Hu J, Bourne RA, McGrath BC, Lin A, Pei Z, Cavener DR: Co-opting regulation bypass repair as a gene-correction strategy for monogenic diseases. Mol Ther, 2021 Nov 3, 29(11):3274-3292.
Ibrahim S, Johnson M, Stephens CH, Xu J, Moore R, Mariani A, Contreras C, Syed F, Mirmira RG, Anderson RM, Sims EK: beta-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs. Mol Metab 2021 Nov, 53:101289.
Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keles S, Moskowitz IP, Keller MP, Attie AD: Identification of direct transcriptional targets of NFATC2 that promote beta cell proliferation. J Clin Invest, 2021 Nov 1, 131(21).
Anderson AM, Landry LG, Alkanani AA, Pyle L, Powers AC, Atkinson MA, Mathews CE, Roep BO, Michels AW, Nakayama M: Human islet T cells are highly reactive to preproinsulin in type 1 diabetes. Proc Natl Acad Sci U S A 2021 Oct 12, 118(41).
Cayabyab F, Nih LR, Yoshihara E: Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes. Front Endocrinol (Lausanne), 2021 Oct, 12:732431.
Liu QR, Zhu M, Zhang P, Mazucanti CH, Huang NS, Lang DL, Chen Q, Auluck P, Marenco S, O'Connell JF, Ferrucci L, Chia CW, Egan JM: Novel Human Insulin Isoforms and Calpha-peptide Product in Islets of Langerhans and Choroid Plexus. Diabetes 2021 Oct 14.
Qi M, Kaddis JS, Chen KT, Rawson J, Omori K, Chen ZB, Dhawan S, Isenberg JS, Kandeel F, Roep BO, Al-Abdullah IH: Chronic marijuana usage by human pancreas donors is associated with impaired islet function. PLoS One 2021 Oct, 16(10):e0258434.
Wu W, Syed F, Simpson E, Lee CC, Liu J, Chang G, Dong C, Seitz C, Eizirik DL, Mirmira RG, Liu Y, Evans-Molina C: The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets. Diabetes 2021 Oct 25.
Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SC, MacDonald PE, Levy SE, Powers AC, Brissova M: Combinatorial transcription factor profiles predict mature and functional human islet alpha and beta cells. JCI Insight 2021 Sep 22, 6(18).
Walker JT, Saunders DC, Brissova M, Powers AC: The Human Islet: Mini-Organ With Mega-Impact. Endocr Rev 2021 Sep 28, 42(5):605-657.
Basile G, Kahraman S, Dirice E, Pan H, Dreyfuss JM, Kulkarni RN: Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets. Genome Med, 2021 Aug 10, 13(1):128.
Bauchle CJ, Rohli KE, Boyer CK, Pal V, Rocheleau JV, Liu S, Imai Y, Taylor EB, Stephens SB: Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet beta-Cell Function. Diabetes 2021 Aug, 70(8):1717-1728.
Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Sorensen J, Li J, Kubicek S: An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation. Mol Metab 2021 Aug 25, 54:101329.
Kaestner KH, Campbell-Thompson M, Dor Y, Gill RG, Glaser B, Kim SK, Sander M, Stabler C, Stewart AF, Powers AC: What is a beta cell? - Chapter I in the Human Islet Research Network (HIRN) review series. Mol Metab 2021 Aug 17, 53:101323.
Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, Pal A, Awal S, Joshi A, Rafizadeh S, Madduri MK, Khazaei M, Liu H, Yuan T, He W, Gorrepati KDD, Azizi Z, Qi Q, Ye K, Oberholzer J, Maedler K, Ardestani A: Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes. Cell Rep 2021 Aug 3, 36(5):109490.
Tahbaz M, Yoshihara E: Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes. Front Endocrinol (Lausanne), 2021 Aug, 12:716625.
Yang GH, Fontaine DA, Lodh S, Blumer JT, Roopra A, Davis DB: TCF19 Impacts a Network of Inflammatory and DNA Damage Response Genes in the Pancreatic beta-Cell. Metabolites 2021 Aug 4, 11(8).
Yuan T, Annamalai K, Naik S, Lupse B, Geravandi S, Pal A, Dobrowolski A, Ghawali J, Ruhlandt M, Gorrepati KDD, Azizi Z, Lim DS, Maedler K, Ardestani A: The Hippo kinase LATS2 impairs pancreatic beta-cell survival in diabetes through the mTORC1-autophagy axis. Nat Commun 2021 Aug 13, 12(1):4928.
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Kumar K, Wang P, Wilson J, Zlatanic V, Berrouet C, Khamrui S, Secor C, Swartz EA, Lazarus M, Sanchez R, Stewart AF, Garcia-Ocana A, DeVita RJ. Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human beta-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor. J Med Chem, 2020 Mar 26, 63(6): 2986-3003.
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Farina M, Ballerini A, Fraga DW, Nicolov E, Hogan M, Demarchi D, Scaglione F, Sabek OM, Horner P, Thekkedath U, Gaber OA, Grattoni A. 3D Printed Vascularized Device for Subcutaneous Transplantation of Human Islets. Biotechnol J, 2017 Sep, 12(9).
Linnemann AK, Blumer J, Marasco MR, Battiola TJ, Umhoefer HM, Han JY, Lamming DW, Davis DB. Interleukin 6 protects pancreatic beta cells from apoptosis by stimulation of autophagy. FASEB J, 2017 Sep, 31(9): 4140-52. PMCID: 5572685.
Makhmutova M, Liang T, Gaisano H, Caicedo A, Almaca J. Confocal Imaging of Neuropeptide Y-pHluorin: A Technique to Visualize Insulin Granule Exocytosis in Intact Murine and Human Islets. J Vis Exp, 2017 Sep, (127). PMCID: 5695231.
Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU, National Institutes of Health Intramural Sequencing Center Comparative Sequencing P, Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL. A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus. Diabetes, 2017 Sep, 66(9): 2521-30.
 Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA: TALK-1 channels control beta cell endoplasmic reticulum Ca(2+) homeostasis. Sci Signal, 2017 Sep 19, 10(497).
Westacott MJ, Farnsworth NL, St Clair JR, Poffenberger G, Heintz A, Ludin NW, Hart NJ, Powers AC, Benninger RKP. Age-Dependent Decline in the Coordinated [Ca(2+)] and Insulin Secretory Dynamics in Human Pancreatic Islets. Diabetes, 2017 Sep, 66(9): 2436-45. PMCID: 5566297.
Ma K, Xiao A, Park SH, Glenn L, Jackson L, Barot T, Weaver JR, Taylor-Fishwick DA, Luci DK, Maloney DJ, Mirmira RG, Imai Y, Nadler JL. 12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets. J Clin Endocrinol Metab, 2017 Aug, 102(8): 2789-97. PMCID: 5546865.
Manzar GS, Kim EM, Zavazava N. Demethylation of induced pluripotent stem cells from type 1 diabetic patients enhances differentiation into functional pancreatic beta cells. J Biol Chem, 2017 Aug, 292(34): 14066-79. PMCID: 5572901.
Zhang Y, Wu M, Htun W, Dong EW, Mauvais-Jarvis F, Fonseca VA, Wu H. Differential Effects of Linagliptin on the Function of Human Islets Isolated from Non-diabetic and Diabetic Donors. Sci Rep, 2017 Aug, 7(1): 7964. PMCID: 5554162.
Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Ruegg MA, Hall MN, Bernal-Mizrachi E. Loss of mTORC1 signalling impairs beta-cell homeostasis and insulin processing. Nat Commun, 2017 Jul, 8: 16014. PMCID: 5510183.
Clark AL, Kanekura K, Lavagnino Z, Spears LD, Abreu D, Mahadevan J, Yagi T, Semenkovich CF, Piston DW, Urano F. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Sci Rep, 2017 Jul, 7(1): 5611. PMCID: 5514111.
Li C, Ackermann AM, Boodhansingh KE, Bhatti TR, Liu C, Schug J, Doliba N, Han B, Cosgrove KE, Banerjee I, Matschinsky FM, Nissim I, Kaestner KH, Naji A, Adzick NS, Dunne MJ, Stanley CA, De Leon DD. Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets. Diabetes, 2017 Jul, 66(7): 1901-13. PMCID: 5482088.
Carboneau BA, Allan JA, Townsend SE, Kimple ME, Breyer RM, Gannon M. Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human beta-cell survival and proliferation. Mol Metab, 2017 Jun, 6(6): 548-59. PMCID: 5444094.
Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC. Interrupted Glucagon Signaling Reveals Hepatic alpha Cell Axis and Role for L-Glutamine in alpha Cell Proliferation. Cell Metab, 2017 Jun, 25(6): 1362-73 e5. PMCID: 5572896.
Lombardi A, Tomer Y. Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress. J Autoimmun, 2017 Jun, 80: 48-55. PMCID: 5758382.
Ocana GJ, Perez L, Guindon L, Deffit SN, Evans-Molina C, Thurmond DC, Blum JS. Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90alpha. Immunology, 2017 Jun, 151(2): 198-210. PMCID: 5418464.
Rawal S, Harrington S, Williams SJ, Ramachandran K, Stehno-Bittel L. Long-term cryopreservation of reaggregated pancreatic islets resulting in successful transplantation in rats. Cryobiology, 2017 Jun, 76: 41-50.
Sims EK, Lakhter AJ, Anderson-Baucum E, Kono T, Tong X, Evans-Molina C. MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells. Diabetologia, 2017 Jun, 60(6): 1057-65. PMCID: 5425307.
Komatsu H, Barriga A, Medrano L, Omori K, Kandeel F, Mullen Y. Oxygenated thawing and rewarming alleviate rewarming injury of cryopreserved pancreatic islets. Biochem Biophys Res Commun, 2017 May, 486(3): 817-23.
Moulle VS, Vivot K, Tremblay C, Zarrouki B, Ghislain J, Poitout V. Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats. Diabetologia, 2017 May, 60(5): 879-88. PMCID: 5376373.
Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA. Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic beta-cells. PLoS One, 2017 Apr, 12(4): e0175069. PMCID: 5389796.
Reissaus CA, Piston DW. Reestablishment of Glucose Inhibition of Glucagon Secretion in Small Pseudoislets. Diabetes, 2017 Apr, 66(4): 960-9. PMCID: 5360306.
Roat R, Hossain MM, Christopherson J, Free C, Jain S, Guay C, Regazzi R, Guo Z. Identification and Characterization of microRNAs Associated With Human beta-Cell Loss in a Mouse Model. Am J Transplant, 2017 Apr, 17(4): 992-1007.
Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A, Kulkarni RN. Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic beta Cell Proliferation. Cell Metab, 2017 Apr, 25(4): 868-82 e5. PMCID: 5382039.
Vallabhajosyula P, Korutla L, Habertheuer A, Yu M, Rostami S, Yuan CX, Reddy S, Liu C, Korutla V, Koeberlein B, Trofe-Clark J, Rickels MR, Naji A. Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue. J Clin Invest, 2017 Apr, 127(4): 1375-91. PMCID: 5373894.
Yuan T, Rafizadeh S, Gorrepati KD, Lupse B, Oberholzer J, Maedler K, Ardestani A. Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes. Diabetologia, 2017 Apr, 60(4): 668-78.
Ansari IH, Longacre MJ, Stoker SW, Kendrick MA, O'Neill LM, Zitur LJ, Fernandez LA, Ntambi JM, MacDonald MJ. Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion. Arch Biochem Biophys, 2017 Mar, 618: 32-43. PMCID: 5445904.
Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes. Diabetes, 2017 Mar, 66(3): 722-34. PMCID: 5319719.
Rui J, Deng S, Arazi A, Perdigoto AL, Liu Z, Herold KC. beta Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice. Cell Metab, 2017 Mar, 25(3): 727-38. PMCID: 5342930.
Wong WP, Allen NB, Meyers MS, Link EO, Zhang X, MacRenaris KW, El Muayed M. Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel. Sci Rep, 2017 Mar, 7(1): 473. PMCID: 5428289.
Coffey R, Knutson MD. The plasma membrane metal-ion transporter ZIP14 contributes to nontransferrin-bound iron uptake by human beta-cells. Am J Physiol Cell Physiol, 2017 Feb, 312(2): C169-C75. PMCID: 5336597.
Lawlor N, George J, Bolisetty M, Kursawe R, Sun L, Sivakamasundari V, Kycia I, Robson P, Stitzel ML. Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes. Genome Res, 2017 Feb, 27(2): 208-22. PMCID: 5287227.
Varshney A, Scott LJ, Welch RP, Erdos MR, Chines PS, Narisu N, Albanus RD, Orchard P, Wolford BN, Kursawe R, Vadlamudi S, Cannon ME, Didion JP, Hensley J, Kirilusha A, Program NCS, Bonnycastle LL, Taylor DL, Watanabe R, Mohlke KL, Boehnke M, Collins FS, Parker SC, Stitzel ML. Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proc Natl Acad Sci U S A, 2017 Feb, 114(9): 2301-6. PMCID: 5338551.
Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic beta cells. J Clin Invest, 2017 Jan, 127(1): 215-29. PMCID: 5199701.
Gutierrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L. Pancreatic beta cell identity requires continual repression of non-beta cell programs. J Clin Invest, 2017 Jan, 127(1): 244-59. PMCID: 5199704.
Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Majek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Sorensen J, Kubicek S. Artemisinins Target GABAA Receptor Signaling and Impair alpha Cell Identity. Cell, 2017 Jan, 168(1-2): 86-100 e15. PMCID: 5236063.
2016 (57)
Almaca J, Molina J, Menegaz D, Pronin AN, Tamayo A, Slepak V, Berggren PO, Caicedo A. Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells. Cell Rep, 2016 Dec, 17(12): 3281-91. PMCID: 5217294.
Babon JA, DeNicola ME, Blodgett DM, Crevecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med, 2016 Dec, 22(12): 1482-7. PMCID: 5140746.
Hayes HL, Zhang L, Becker TC, Haldeman JM, Stephens SB, Arlotto M, Moss LG, Newgard CB, Hohmeier HE. A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation. Mol Cell Biol, 2016 Dec, 36(23): 2918-30. PMCID: 5108880.
Jing G, Chen J, Xu G, Shalev A. Islet ChREBP-beta is increased in diabetes and controls ChREBP-alpha and glucose-induced gene expression via a negative feedback loop. Mol Metab, 2016 Dec, 5(12): 1208-15. PMCID: 5123192.
Keller MP, Paul PK, Rabaglia ME, Stapleton DS, Schueler KL, Broman AT, Ye SI, Leng N, Brandon CJ, Neto EC, Plaisier CL, Simonett SP, Kebede MA, Sheynkman GM, Klein MA, Baliga NS, Smith LM, Broman KW, Yandell BS, Kendziorski C, Attie AD. The Transcription Factor Nfatc2 Regulates beta-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets. PLoS Genet, 2016 Dec, 12(12): e1006466. PMCID: 5147809.
Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM: Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. JCI Insight, 2016 Dec 8, 1(20):e88242.
ang P, Moore A. In Vivo Magnetic Resonance Imaging of Small Interfering RNA Nanodelivery to Pancreatic Islets. Methods Mol Biol, 2016 Dec, 1372: 25-36.
Aamodt KI, Aramandla R, Brown JJ, Fiaschi-Taesch N, Wang P, Stewart AF, Brissova M, Powers AC. Development of a reliable automated screening system to identify small molecules and biologics that promote human beta-cell regeneration. Am J Physiol Endocrinol Metab, 2016 Nov, 311(5): E859-E68. PMCID: 5130356.
Amin J, Ramachandran K, Williams SJ, Lee A, Novikova L, Stehno-Bittel L. A simple, reliable method for high-throughput screening for diabetes drugs using 3D beta-cell spheroids. J Pharmacol Toxicol Methods, 2016 Nov, 82: 83-9.
Houtz J, Borden P, Ceasrine A, Minichiello L, Kuruvilla R. Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion. Dev Cell, 2016 Nov, 39(3): 329-45. PMCID: 5123838.
Yuan T, Rafizadeh S, Azizi Z, Lupse B, Gorrepati KD, Awal S, Oberholzer J, Maedler K, Ardestani A. Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic beta cells. JCI Insight, 2016 Nov, 1(18): e86326. PMCID: 5085606.
Ahn M, Yoder SM, Wang Z, Oh E, Ramalingam L, Tunduguru R, Thurmond DC. The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets. Diabetologia, 2016 Oct, 59(10): 2145-55. PMCID: 5266538.
Komatsu H, Omori K, Parimi M, Rawson J, Kandeel F, Mullen Y. Determination of Islet Viability Using a Zinc-Specific Fluorescent Dye and a Semiautomated Assessment Method. Cell Transplant, 2016 Oct, 25(10): 1777-86.
Wang YJ, Golson ML, Schug J, Traum D, Liu C, Vivek K, Dorrell C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH. Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metab, 2016 Oct, 24(4): 616-26. PMCID: 5123805.
Duan H, Lee JW, Moon SW, Arora D, Li Y, Lim HY, Wang W. Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic beta-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress. J Med Chem, 2016 Sep, 59(17): 7783-800. PMCID: 5180602.
Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ. Pancreatic beta-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity. Diabetes, 2016 Sep, 65(9): 2700-10. PMCID: 5001174.
Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attane C, Moulle VS, MacDonald PE, Ghislain J, Poitout V. Urea impairs beta cell glycolysis and insulin secretion in chronic kidney disease. J Clin Invest, 2016 Sep, 126(9): 3598-612. PMCID: 5004963.
Shah P, Lueschen N, Ardestani A, Oberholzer J, Olerud J, Carlsson PO, Maedler K. Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes. PLoS One, 2016 Sep, 11(9): e0161834. PMCID: 5019443.
Singh S, Trikha S, Sarkar A, Jeremic AM. Proteasome regulates turnover of toxic human amylin in pancreatic cells. Biochem J, 2016 Sep, 473(17): 2655-70. PMCID: 5056598.
Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM. G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology, 2016 Aug, 157(8): 3002-8. PMCID: 4967123.
DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, van der Meulen T, Huising MO. Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets. Mol Metab, 2016 Jul, 5(7): 449-58. PMCID: 4921781.
Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M. Human islets contain four distinct subtypes of beta cells. Nat Commun, 2016 Jul, 7: 11756. PMCID: 4942571.
Li G, Wu B, Ward MG, Chong AC, Mukherjee S, Chen S, Hao M. Multifunctional in vivo imaging of pancreatic islets during diabetes development. J Cell Sci, 2016 Jul, 129(14): 2865-75. PMCID: 4958299.
Saunders D, Powers AC. Replicative capacity of beta-cells and type 1 diabetes. J Autoimmun, 2016 Jul, 71: 59-68. PMCID: 4903931.
Ansarullah, Free C, Christopherson J, Chen Q, Gao J, Liu C, Naji A, Rabinovitch A, Guo Z. Activation of GPR119 Stimulates Human beta-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets. J Diabetes Res, 2016 Jun, 2016: 1620821. PMCID: 4927982.
Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dancik V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A Stimulates Human beta-Cell Proliferation. Diabetes, 2016 Jun, 65(6): 1660-71. PMCID: 4878416.
Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y. Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming. Am J Physiol Endocrinol Metab, 2016 Jun, 310(11): E1016-26. PMCID: 4935146.
Zhang C, Caldwell TA, Mirbolooki MR, Duong D, Park EJ, Chi NW, Chessler SD. Extracellular CADM1 interactions influence insulin secretion by rat and human islet beta-cells and promote clustering of syntaxin-1. Am J Physiol Endocrinol Metab, 2016 Jun, 310(11): E874-85. PMCID: 4935136.
Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK. Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human beta Cell Function. Cell Metab, 2016 May, 23(5): 909-20. PMCID: 4864151.
Arifin DR, Valdeig S, Anders RA, Bulte JW, Weiss CR. Magnetoencapsulated human islets xenotransplanted into swine: a comparison of different transplantation sites. Xenotransplantation, 2016 May, 23(3): 211-21. PMCID: PMC5027196.
Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C, Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD, Stein R, Powers AC. Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. J Clin Invest, 2016 May, 126(5): 1857-70. PMCID: 4855919.
Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-beta Signaling Promotes Human Pancreatic beta-Cell Replication. Diabetes, 2016 May, 65(5): 1208-18. PMCID: 4839200.
Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF. Trimeprazine increases IRS2 in human islets and promotes pancreatic beta cell growth and function in mice. JCI Insight, 2016 May, 1(3). PMCID: 4854304.
Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocana A. PKCzeta Is Essential for Pancreatic beta-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes, 2016 May, 65(5): 1283-96. PMCID: 4839210.
Navarro G, Xu W, Jacobson DA, Wicksteed B, Allard C, Zhang G, De Gendt K, Kim SH, Wu H, Zhang H, Verhoeven G, Katzenellenbogen JA, Mauvais-Jarvis F. Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male. Cell Metab, 2016 May, 23(5): 837-51. PMCID: 4864089.
Robles L, Vaziri ND, Li S, Masuda Y, Takasu C, Takasu M, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA) Ameliorates Acute Pancreatitis. Pancreas, 2016 May, 45(5): 720-9. PMCID: 5847282.
Rui J, Deng S, Lebastchi J, Clark PL, Usmani-Brown S, Herold KC. Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice. Diabetologia, 2016 May, 59(5): 1021-9. PMCID: 4826795.
Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I. p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion. Nat Med, 2016 Apr, 22(4): 412-20. PMCID: 5546206.
Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH. Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in beta-Cells. ACS Chem Biol, 2016 Apr, 11(4): 1128-36. PMCID: 5198576.
Nourmohammadzadeh M, Xing Y, Lee JW, Bochenek MA, Mendoza-Elias JE, McGarrigle JJ, Marchese E, Chun-Chieh Y, Eddington DT, Oberholzer J, Wang Y. A microfluidic array for real-time live-cell imaging of human and rodent pancreatic islets. Lab Chip, 2016 Apr, 16(8): 1466-72.
Olsen JA, Kenna LA, Spelios MG, Hessner MJ, Akirav EM. Circulating Differentially Methylated Amylin DNA as a Biomarker of beta-Cell Loss in Type 1 Diabetes. PLoS One, 2016 Apr, 11(4): e0152662. PMCID: 4844136.
Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NA, O'Donnell CP, Garcia-Ocana A, Alonso LC. Glucose Induces Mouse beta-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor. Diabetes, 2016 Apr, 65(4): 981-95. PMCID: 5314707.
Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng T, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. ERRgamma Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive beta Cells. Cell Metab, 2016 Apr, 23(4): 622-34. PMCID: 4832237.
Abdulreda MH, Rodriguez-Diaz R, Caicedo A, Berggren PO. Liraglutide Compromises Pancreatic beta Cell Function in a Humanized Mouse Model. Cell Metab, 2016 Mar, 23(3): 541-6. PMCID: 4785083.
Ackermann AM, Wang Z, Schug J, Naji A, Kaestner KH. Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes. Mol Metab, 2016 Mar, 5(3): 233-44. PMCID: 4770267.
Gonzalez-Mariscal I, Krzysik-Walker SM, Kim W, Rouse M, Egan JM. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. Mol Cell Endocrinol, 2016 Mar, 423: 1-10. PMCID: 4752920.
Farnsworth NL, Walter RL, Hemmati A, Westacott MJ, Benninger RK. Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cdelta. J Biol Chem, 2016 Feb, 291(7): 3184-96. PMCID: 4751367.
Friedman-Mazursky O, Elkon R, Efrat S. Redifferentiation of expanded human islet beta cells by inhibition of ARX. Sci Rep, 2016 Feb, 6: 20698. PMCID: 4746595.
Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L, Rittenhouse A, Harlan D, Greiner D, Bortell R. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic beta-cell function via glycogen synthase kinase-3beta. FASEB J, 2016 Feb, 30(2): 983-93. PMCID: 4714549.
Komatsu H, Kang D, Medrano L, Barriga A, Mendez D, Rawson J, Omori K, Ferreri K, Tai YC, Kandeel F, Mullen Y. Isolated human islets require hyperoxia to maintain islet mass, metabolism, and function. Biochem Biophys Res Commun, 2016 Feb, 470(3): 534-8.
Pauerstein PT, Park KM, Peiris HS, Wang J, Kim SK. Research Resource: Genetic Labeling of Human Islet Alpha Cells. Mol Endocrinol, 2016 Feb, 30(2): 248-53. PMCID: 4792229.
Robitaille K, Rourke JL, McBane JE, Fu A, Baird S, Du Q, Kin T, Shapiro AM, Screaton RA. High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation. J Biol Chem, 2016 Feb, 291(9): 4614-25. PMCID: 4813485.
Yuan T, Gorrepati KD, Maedler K, Ardestani A. Loss of Merlin/NF2 protects pancreatic beta-cells from apoptosis by inhibiting LATS2. Cell Death Dis, 2016 Feb, 7: e2107. PMCID: 5399191.
Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT, Jr., Powers AC, Gu G, Stein R. The MAFB transcription factor impacts islet alpha-cell function in rodents and represents a unique signature of primate islet beta-cells. Am J Physiol Endocrinol Metab, 2016 Jan, 310(1): E91-E102. PMCID: 4675799.
El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic beta Cell Proliferation. Cell Metab, 2016 Jan, 23(1): 194-205. PMCID: 4715773.
Kryvalap Y, Lo CW, Manuylova E, Baldzizhar R, Jospe N, Czyzyk J. Antibody Response to Serpin B13 Induces Adaptive Changes in Mouse Pancreatic Islets and Slows Down the Decline in the Residual Beta Cell Function in Children with Recent Onset of Type 1 Diabetes Mellitus. J Biol Chem, 2016 Jan, 291(1): 266-78. PMCID: 4697161.
Sabek OM, Farina M, Fraga DW, Afshar S, Ballerini A, Filgueira CS, Thekkedath UR, Grattoni A, Gaber AO. Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment. J Tissue Eng, 2016 Jan, 7: 2041731416638198. PMCID: 4843232.
2015 (45)
Almaca J, Liang T, Gaisano HY, Nam HG, Berggren PO, Caicedo A. Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets. Diabetologia, 2015 Dec, 58(12): 2810-8.
Galloway JR, Bethea M, Liu Y, Underwood R, Mobley JA, Hunter CS. SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic beta-Cell Target Genes. Mol Endocrinol, 2015 Dec, 29(12): 1774-86. PMCID: 4664226.
Klein D, Alvarez-Cubela S, Lanzoni G, Vargas N, Prabakar KR, Boulina M, Ricordi C, Inverardi L, Pastori RL, Dominguez-Bendala J. BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion. Diabetes, 2015 Dec, 64(12): 4123-34. PMCID: 4657585.
Wu Y, Shyng SL, Chen PC. Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic beta-Cells. J Biol Chem, 2015 Dec, 290(50): 29676-90. PMCID: 4705974.
Zhang P, Kumar A, Katz LS, Li L, Paulynice M, Herman MA, Scott DK. Induction of the ChREBPbeta Isoform Is Essential for Glucose-Stimulated beta-Cell Proliferation. Diabetes, 2015 Dec, 64(12): 4158-70. PMCID: 4657577.
Chen H, Kleinberger JW, Takane KK, Salim F, Fiaschi-Taesch N, Pappas K, Parsons R, Jiang J, Zhang Y, Liu H, Wang P, Bender AS, Frank SJ, Stewart AF. Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human beta-Cells. Diabetes, 2015 Nov, 64(11): 3784-97. PMCID: 4613973.
Hutchens T, Piston DW. EphA4 Receptor Forward Signaling Inhibits Glucagon Secretion From alpha-Cells. Diabetes, 2015 Nov, 64(11): 3839-51. PMCID: 4613968.
Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE. Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells. Cell Mol Gastroenterol Hepatol, 2015 Nov, 1(6): 695-709. PMCID: 4657148.
Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA. Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates beta-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis. Diabetes, 2015 Nov, 64(11): 3818-28. PMCID: 4613978.
Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC. Insulin demand regulates beta cell number via the unfolded protein response. J Clin Invest, 2015 Oct, 125(10): 3831-46. PMCID: 4607122.
Truchan NA, Brar HK, Gallagher SJ, Neuman JC, Kimple ME. A single-islet microplate assay to measure mouse and human islet insulin secretion. Islets, 2015 Oct, 7(3): e1076607. PMCID: 4708880.
Ansari IU, Longacre MJ, Paulusma CC, Stoker SW, Kendrick MA, MacDonald MJ. Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION. J Biol Chem, 2015 Sep, 290(38): 23110-23. PMCID: 4645617.
Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes, 2015 Sep, 64(9): 3172-81. PMCID: 4542439.
Oleson BJ, McGraw JA, Broniowska KA, Annamalai M, Chen J, Bushkofsky JR, Davis DB, Corbett JA, Mathews CE. Distinct differences in the responses of the human pancreatic beta-cell line EndoC-betaH1 and human islets to proinflammatory cytokines. Am J Physiol Regul Integr Comp Physiol, 2015 Sep, 309(5): R525-34. PMCID: 4591379.
Qi M, McFadden B, Valiente L, Omori K, Bilbao S, Juan J, Rawson J, Oancea AR, Scott S, Nair I, Ferreri K, Mullen Y, Dafoe D, Ei-Shahawy M, Kandeel F, Al-Abdullah IH. Human Pancreatic Islets Isolated From Donors With Elevated HbA1c Levels: Islet Yield and Graft Efficacy. Cell Transplant, 2015 Sep, 24(9): 1879-86.
Papas KK, Bellin MD, Sutherland DE, Suszynski TM, Kitzmann JP, Avgoustiniatos ES, Gruessner AC, Mueller KR, Beilman GJ, Balamurugan AN, Loganathan G, Colton CK, Koulmanda M, Weir GC, Wilhelm JJ, Qian D, Niland JC, Hering BJ. Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation. PLoS One, 2015 Aug, 10(8): e0134428. PMCID: 4530873.
Sintov E, Nathan G, Knoller S, Pasmanik-Chor M, Russ HA, Efrat S. Inhibition of ZEB1 expression induces redifferentiation of adult human beta cells expanded in vitro. Sci Rep, 2015 Aug, 5: 13024. PMCID: 4532995.
Yang C, Loehn M, Jurczyk A, Przewozniak N, Leehy L, Herrera PL, Shultz LD, Greiner DL, Harlan DM, Bortell R. Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets. Diabetes Metab Syndr Obes, 2015 Aug, 8: 387-98. PMCID: 4548726.
Dhawan S, Tschen SI, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A. DNA methylation directs functional maturation of pancreatic beta cells. J Clin Invest, 2015 Jul, 125(7): 2851-60. PMCID: 4563682.
Kondegowda NG, Fenutria R, Pollack IR, Orthofer M, Garcia-Ocana A, Penninger JM, Vasavada RC. Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-kappaB Ligand Pathway. Cell Metab, 2015 Jul, 22(1): 77-85. PMCID: 4597781.
Linnemann AK, Neuman JC, Battiola TJ, Wisinski JA, Kimple ME, Davis DB. Glucagon-Like Peptide-1 Regulates Cholecystokinin Production in beta-Cells to Protect From Apoptosis. Mol Endocrinol, 2015 Jul, 29(7): 978-87. PMCID: 4484781.
Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT. An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion. Mol Endocrinol, 2015 Jul, 29(7): 1055-66. PMCID: 4484778.
van der Meulen T, Donaldson CJ, Caceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med, 2015 Jul, 21(7): 769-76. PMCID: 4496282.
Masuda Y, Vaziri ND, Li S, Le A, Hajighasemi-Ossareh M, Robles L, Foster CE, Stamos MJ, Al-Abodullah I, Ricordi C, Ichii H. The effect of Nrf2 pathway activation on human pancreatic islet cells. PLoS One, 2015 Jun, 10(6): e0131012. PMCID: 4482439.
Omori K, Komatsu H, Rawson J, Mullen Y. Pharmacological strategies for protection of extrahepatic islet transplantation. Minerva Endocrinol, 2015 Jun, 40(2): 85-103.
Tong X, Kono T, Evans-Molina C. Nitric oxide stress and activation of AMP-activated protein kinase impair beta-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability. Cell Death Dis, 2015 Jun, 6: e1790. PMCID: 4669835.
Burke SJ, May AL, Noland RC, Lu D, Brissova M, Powers AC, Sherrill EM, Karlstad MD, Campagna SR, Stephens JM, Collier JJ. Thiobenzothiazole-modified Hydrocortisones Display Anti-inflammatory Activity with Reduced Impact on Islet beta-Cell Function. J Biol Chem, 2015 May, 290(21): 13401-16. PMCID: 4505588.
Costes S, Boss M, Thomas AP, Matveyenko AV. Activation of Melatonin Signaling Promotes beta-Cell Survival and Function. Mol Endocrinol, 2015 May, 29(5): 682-92. PMCID: 4415205.
Dadi PK, Luo B, Vierra NC, Jacobson DA. TASK-1 Potassium Channels Limit Pancreatic alpha-Cell Calcium Influx and Glucagon Secretion. Mol Endocrinol, 2015 May, 29(5): 777-87. PMCID: 4415209.
Qi M, Valiente L, McFadden B, Omori K, Bilbao S, Juan J, Rawson J, Scott S, Ferreri K, Mullen Y, El-Shahawy M, Dafoe D, Kandeel F, Al-Abdullah IH. The Choice of Enzyme for Human Pancreas Digestion is a Critical Factor for Increasing the Success of Islet Isolation. Transplant Direct, 2015 May, 1(4). PMCID: 4486320.
Ramachandran K, Huang HH, Stehno-Bittel L. A Simple Method to Replace Islet Equivalents for Volume Quantification of Human Islets. Cell Transplant, 2015 May, 24(7): 1183-94.
Tiano JP, Tate CR, Yang BS, DiMarchi R, Mauvais-Jarvis F. Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis. Sci Rep, 2015 May, 5: 10211. PMCID: 4429560.
Gallagher GR, Brehm MA, Finberg RW, Barton BA, Shultz LD, Greiner DL, Bortell R, Wang JP. Viral infection of engrafted human islets leads to diabetes. Diabetes, 2015 Apr, 64(4): 1358-69. PMCID: 4375078.
Kayton NS, Poffenberger G, Henske J, Dai C, Thompson C, Aramandla R, Shostak A, Nicholson W, Brissova M, Bush WS, Powers AC. Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles. Am J Physiol Endocrinol Metab, 2015 Apr, 308(7): E592-602. PMCID: 4385877.
Maffei A, Segal AM, Alvarez-Perez JC, Garcia-Ocana A, Harris PE. Anti-incretin, Anti-proliferative Action of Dopamine on beta-Cells. Mol Endocrinol, 2015 Apr, 29(4): 542-57. PMCID: 4399277.
Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen MS, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik MS, Heise T, Berggren PO, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E. Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. Nat Med, 2015 Apr, 21(4): 363-72.
Trevino MB, Machida Y, Hallinger DR, Garcia E, Christensen A, Dutta S, Peake DA, Ikeda Y, Imai Y. Perilipin 5 regulates islet lipid metabolism and insulin secretion in a cAMP-dependent manner: implication of its role in the postprandial insulin secretion. Diabetes, 2015 Apr, 64(4): 1299-310. PMCID: 4375085.
Wang P, Alvarez-Perez JC, Felsenfeld DP, Liu H, Sivendran S, Bender A, Kumar A, Sanchez R, Scott DK, Garcia-Ocana A, Stewart AF. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med, 2015 Apr, 21(4): 383-8. PMCID: 4690535.
Wang P, Fiaschi-Taesch NM, Vasavada RC, Scott DK, Garcia-Ocana A, Stewart AF. Diabetes mellitus--advances and challenges in human beta-cell proliferation. Nat Rev Endocrinol, 2015 Apr, 11(4): 201-12.
Jimenez-Palomares M, Lopez-Acosta JF, Villa-Perez P, Moreno-Amador JL, Munoz-Barrera J, Fernandez-Luis S, Heras-Pozas B, Perdomo G, Bernal-Mizrachi E, Cozar-Castellano I. Cyclin C stimulates beta-cell proliferation in rat and human pancreatic beta-cells. Am J Physiol Endocrinol Metab, 2015 Mar, 308(6): E450-9. PMCID: 4360017.
Qi M, Luis V, Bilbao S, Omori K, Rawson J, McFadden B, Juan J, Nair I, Mullen Y, El-Shahawy M, Dafoe D, Kandeel F, Al-Abdullah IH. Sodium levels of human pancreatic donors are a critical factor for determination of islet efficacy and survival. Am J Physiol Endocrinol Metab, 2015 Mar, 308(5): E362-9.
Alfa RW, Park S, Skelly KR, Poffenberger G, Jain N, Gu X, Kockel L, Wang J, Liu Y, Powers AC, Kim SK. Suppression of insulin production and secretion by a decretin hormone. Cell Metab, 2015 Feb, 21(2): 323-34. PMCID: 4349554. Published Erratum: . Cell Metab, 2018 Feb, 27(2): 479. PMCID: 5963682.
Lawrence MC, Borenstein-Auerbach N, McGlynn K, Kunnathodi F, Shahbazov R, Syed I, Kanak M, Takita M, Levy MF, Naziruddin B. NFAT targets signaling molecules to gene promoters in pancreatic beta-cells. Mol Endocrinol, 2015 Feb, 29(2): 274-88. PMCID: 4318885.
Elliott AD, Ustione A, Piston DW. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic alpha-cell by lowering cAMP. Am J Physiol Endocrinol Metab, 2015 Jan, 308(2): E130-43. PMCID: 4297778.
Luo LG, Xiong F, Ravassard P, Luo JZ. Human Bone Marrow Subpopulations Sustain Human Islet Function and Viability In vitro. Br J Med Med Res, 2015 Jan, 8(7): 576-87. PMCID: 4837454.
2014 (32)
Almaca J, Molina J, Arrojo EDR, Abdulreda MH, Jeon WB, Berggren PO, Caicedo A, Nam HG. Young capillary vessels rejuvenate aged pancreatic islets. Proc Natl Acad Sci U S A, 2014 Dec, 111(49): 17612-7. PMCID: 4267392.
Blaabjerg L, Christensen GL, Matsumoto M, van der Meulen T, Huising MO, Billestrup N, Vale WW. CRFR1 activation protects against cytokine-induced beta-cell death. J Mol Endocrinol, 2014 Dec, 53(3): 417-27. PMCID: 4518718.
Kulkarni RN, Stewart AF. Summary of the Keystone islet workshop (April 2014): the increasing demand for human islet availability in diabetes research. Diabetes, 2014 Dec, 63(12): 3979-81. PMCID: 4238004.
Ramalingam L, Lu J, Hudmon A, Thurmond DC. Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet beta-cells. Biochem J, 2014 Dec, 464(2): 251-8. PMCID: 4418448.
Johnson JS, Kono T, Tong X, Yamamoto WR, Zarain-Herzberg A, Merrins MJ, Satin LS, Gilon P, Evans-Molina C. Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet beta cell. J Biol Chem, 2014 Nov, 289(47): 32798-810. PMCID: 4239629.
Liu C, Wu H. From Beta cell replacement to beta cell regeneration: implications for antidiabetic therapy. J Diabetes Sci Technol, 2014 Nov, 8(6): 1221-6. PMCID: 4455474.
Rouse M, Younes A, Egan JM. Resveratrol and curcumin enhance pancreatic beta-cell function by inhibiting phosphodiesterase activity. J Endocrinol, 2014 Nov, 223(2): 107-17. PMCID: 4191183.
Dadi PK, Vierra NC, Jacobson DA. Pancreatic beta-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance. Endocrinology, 2014 Oct, 155(10): 3757-68. PMCID: 4164933.
Qi M, Kinzer K, Danielson KK, Martellotto J, Barbaro B, Wang Y, Bui JT, Gaba RC, Knuttinen G, Garcia-Roca R, Tzvetanov I, Heitman A, Davis M, McGarrigle JJ, Benedetti E, Oberholzer J. Five-year follow-up of patients with type 1 diabetes transplanted with allogeneic islets: the UIC experience. Acta Diabetol, 2014 Oct, 51(5): 833-43. PMCID: 4801517.
Lei X, Bone RN, Ali T, Zhang S, Bohrer A, Tse HM, Bidasee KR, Ramanadham S. Evidence of contribution of iPLA2beta-mediated events during islet beta-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2beta in T1D development. Endocrinology, 2014 Sep, 155(9): 3352-64. PMCID: 4138580.
Robles L, Vaziri ND, Li S, Masuda Y, Takasu C, Takasu M, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Dimethyl fumarate protects pancreatic islet cells and non-endocrine tissue in L-arginine-induced chronic pancreatitis. PLoS One, 2014 Sep, 9(9): e107111. PMCID: 4157838.
Kim W, Fiori JL, Shin YK, Okun E, Kim JS, Rapp PR, Egan JM. Pancreatic polypeptide inhibits somatostatin secretion. FEBS Lett, 2014 Aug, 588(17): 3233-9. PMCID: 4143909.
Manzar GS, Kim EM, Rotti P, Zavazava N. Skin deep: from dermal fibroblasts to pancreatic beta cells. Immunol Res, 2014 Aug, 59(1-3): 279-86.
Molina J, Rodriguez-Diaz R, Fachado A, Jacques-Silva MC, Berggren PO, Caicedo A. Control of insulin secretion by cholinergic signaling in the human pancreatic islet. Diabetes, 2014 Aug, 63(8): 2714-26. PMCID: 4113066.
Rivera JF, Costes S, Gurlo T, Glabe CG, Butler PC. Autophagy defends pancreatic beta cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest, 2014 Aug, 124(8): 3489-500. PMCID: 4109537.
Benner C, van der Meulen T, Caceres E, Tigyi K, Donaldson CJ, Huising MO. The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression. BMC Genomics, 2014 Jul, 15: 620. PMCID: 4124169.
Hlavaty KA, Gibly RF, Zhang X, Rives CB, Graham JG, Lowe WL, Jr., Luo X, Shea LD. Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. Am J Transplant, 2014 Jul, 14(7): 1523-32. PMCID: 4232190.
Kitzmann JP, Pepper AR, Gala-Lopez B, Pawlick R, Kin T, O'Gorman D, Mueller KR, Gruessner AC, Avgoustiniatos ES, Karatzas T, Szot GL, Posselt AM, Stock PG, Wilson JR, Shapiro AM, Papas KK. Human islet viability and function is maintained during high-density shipment in silicone rubber membrane vessels. Transplant Proc, 2014 Jul, 46(6): 1989-91. PMCID: 4169700.
Kono TM, Sims EK, Moss DR, Yamamoto W, Ahn G, Diamond J, Tong X, Day KH, Territo PR, Hanenberg H, Traktuev DO, March KL, Evans-Molina C. Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors. Stem Cells, 2014 Jul, 32(7): 1831-42. PMCID: 4063872.
Brown ML, Ungerleider N, Bonomi L, Andrzejewski D, Burnside A, Schneyer A. Effects of activin A on survival, function and gene expression of pancreatic islets from non-diabetic and diabetic human donors. Islets, 2014 Jun, 6(5-6): e1017226. PMCID: 4398300.
Ramachandran K, Peng X, Bokvist K, Stehno-Bittel L. Assessment of re-aggregated human pancreatic islets for secondary drug screening. Br J Pharmacol, 2014 Jun, 171(12): 3010-22. PMCID: 4055202.
Metzger DE, Liu C, Ziaie AS, Naji A, Zaret KS. Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic beta-cells while repressing alpha-cell functions. Diabetes, 2014 May, 63(5): 1804-16. PMCID: 3994953.
Oh E, Stull ND, Mirmira RG, Thurmond DC. Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus. J Clin Endocrinol Metab, 2014 May, 99(5): E866-70. PMCID: 4010690.
Ardestani A, Paroni F, Azizi Z, Kaur S, Khobragade V, Yuan T, Frogne T, Tao W, Oberholzer J, Pattou F, Conte JK, Maedler K. MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nat Med, 2014 Apr, 20(4): 385-97. PMCID: 3981675.
Husseiny MI, Kaye A, Zebadua E, Kandeel F, Ferreri K. Tissue-specific methylation of human insulin gene and PCR assay for monitoring beta cell death. PLoS One, 2014 Apr, 9(4): e94591. PMCID: 3983232.
Jiao Y, Le Lay J, Yu M, Naji A, Kaestner KH. Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting. Diabetes, 2014 Apr, 63(4): 1283-8. PMCID: 3964501.
Brissova M, Aamodt K, Brahmachary P, Prasad N, Hong JY, Dai C, Mellati M, Shostak A, Poffenberger G, Aramandla R, Levy SE, Powers AC. Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes beta cell regeneration. Cell Metab, 2014 Mar, 19(3): 498-511. PMCID: 4012856.
Butcher MJ, Hallinger D, Garcia E, Machida Y, Chakrabarti S, Nadler J, Galkina EV, Imai Y. Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes. Diabetologia, 2014 Mar, 57(3): 491-501. PMCID: 3966210.
Avrahami D, Li C, Yu M, Jiao Y, Zhang J, Naji A, Ziaie S, Glaser B, Kaestner KH. Targeting the cell cycle inhibitor p57Kip2 promotes adult human beta cell replication. J Clin Invest, 2014 Feb, 124(2): 670-4. PMCID: 3904605.
Kulzer JR, Stitzel ML, Morken MA, Huyghe JR, Fuchsberger C, Kuusisto J, Laakso M, Boehnke M, Collins FS, Mohlke KL. A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell. Am J Hum Genet, 2014 Feb, 94(2): 186-97. PMCID: 3928648.
Kameswaran V, Bramswig NC, McKenna LB, Penn M, Schug J, Hand NJ, Chen Y, Choi I, Vourekas A, Won KJ, Liu C, Vivek K, Naji A, Friedman JR, Kaestner KH. Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metab, 2014 Jan, 19(1): 135-45. PMCID: 3932527.
Szlyk B, Braun CR, Ljubicic S, Patton E, Bird GH, Osundiji MA, Matschinsky FM, Walensky LD, Danial NN. A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators. Nat Struct Mol Biol, 2014 Jan, 21(1): 36-42. PMCID: 4084830.
2013 (42)
Fotino C, Molano RD, Ricordi C, Pileggi A. Transdisciplinary approach to restore pancreatic islet function. Immunol Res, 2013 Dec, 57(1-3): 210-21.
Pileggi A, Klein D, Fotino C, Bravo-Egana V, Rosero S, Doni M, Podetta M, Ricordi C, Molano RD, Pastori RL. MicroRNAs in islet immunobiology and transplantation. Immunol Res, 2013 Dec, 57(1-3): 185-96.
Chen PC, Kryukova YN, Shyng SL. Leptin regulates KATP channel trafficking in pancreatic beta-cells by a signaling mechanism involving AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (PKA). J Biol Chem, 2013 Nov, 288(47): 34098-109. PMCID: PMC3837151./td>
Jaroch DB, Lu J, Madangopal R, Stull ND, Stensberg M, Shi J, Kahn JL, Herrera-Perez R, Zeitchek M, Sturgis J, Robinson JP, Yoder MC, Porterfield DM, Mirmira RG, Rickus JL. Mouse and human islets survive and function after coating by biosilicification. Am J Physiol Endocrinol Metab, 2013 Nov, 305(10): E1230-40. PMCID: 3840215.
Fiori JL, Shin YK, Kim W, Krzysik-Walker SM, Gonzalez-Mariscal I, Carlson OD, Sanghvi M, Moaddel R, Farhang K, Gadkaree SK, Doyle ME, Pearson KJ, Mattison JA, de Cabo R, Egan JM. Resveratrol prevents beta-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes, 2013 Oct, 62(10): 3500-13. PMCID: 3781448.
Hayes HL, Moss LG, Schisler JC, Haldeman JM, Zhang Z, Rosenberg PB, Newgard CB, Hohmeier HE. Pdx-1 activates islet alpha- and beta-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. Mol Cell Biol, 2013 Oct, 33(20): 4017-29. PMCID: 3811680.
Imai Y, Dobrian AD, Weaver JR, Butcher MJ, Cole BK, Galkina EV, Morris MA, Taylor-Fishwick DA, Nadler JL. Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease. Diabetes Obes Metab, 2013 Sep, 15 Suppl 3: 117-29. PMCID: 3777698.
Katz LS, Geras-Raaka E, Gershengorn MC. Reprogramming adult human dermal fibroblasts to islet-like cells by epigenetic modification coupled to transcription factor modulation. Stem Cells Dev, 2013 Sep, 22(18): 2551-60. PMCID: 3760074.
Krautkramer KA, Linnemann AK, Fontaine DA, Whillock AL, Harris TW, Schleis GJ, Truchan NA, Marty-Santos L, Lavine JA, Cleaver O, Kimple ME, Davis DB. Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 beta-cell line. Am J Physiol Endocrinol Metab, 2013 Sep, 305(5): E600-10. PMCID: 3761170.
Liao X, Xue H, Wang YC, Nazor KL, Guo S, Trivedi N, Peterson SE, Liu Y, Loring JF, Laurent LC. Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions. J Cell Sci, 2013 Sep, 126(Pt 17): 3848-61. PMCID: 3757328.
Sabek OM, Ferrati S, Fraga DW, Sih J, Zabre EV, Fine DH, Ferrari M, Gaber AO, Grattoni A. Characterization of a nanogland for the autotransplantation of human pancreatic islets. Lab Chip, 2013 Sep, 13(18): 3675-88.
Trikha S, Jeremic AM. Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cells. PLoS One, 2013 Sep Epub, 8(9): e73080. PMCID: 3760900.
Wu H, Wen D, Mahato RI. Third-party mesenchymal stem cells improved human islet transplantation in a humanized diabetic mouse model. Mol Ther, 2013 Sep, 21(9): 1778-86. PMCID: 3776634.
Guo S, Dai C, Guo M, Taylor B, Harmon JS, Sander M, Robertson RP, Powers AC, Stein R. Inactivation of specific beta cell transcription factors in type 2 diabetes. J Clin Invest, 2013 Aug, 123(8): 3305-16. PMCID: 3726150.
Chen PC, Olson EM, Zhou Q, Kryukova Y, Sampson HM, Thomas DY, Shyng SL. Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism. J Biol Chem, 2013 Jul, 288(29): 20942-54. PMCID: PMC3774364./td>
Fiaschi-Taesch NM, Kleinberger JW, Salim FG, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Scott DK, Stewart AF. Human pancreatic beta-cell G1/S molecule cell cycle atlas. Diabetes, 2013 Jul, 62(7): 2450-9. PMCID: 3712053.
Fiaschi-Taesch NM, Kleinberger JW, Salim FG, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Srinivas H, Scott DK, Stewart AF. Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human beta-cell replication: a revised model of human beta-cell G1/S control. Diabetes, 2013 Jul, 62(7): 2460-70. PMCID: 3712040.
Ma Z, Moruzzi N, Catrina SB, Hals I, Oberholzer J, Grill V, Bjorklund A. Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic beta-cells. PLoS One, 2013 Jul, 8(7): e67498. PMCID: 3723782.
Stein J, Milewski WM, Dey A. The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic beta-cells and restrict their ability to proliferate. Islets, 2013 Jul, 5(4): 156-69. PMCID: 4049839.
Aly H, Rohatgi N, Marshall CA, Grossenheider TC, Miyoshi H, Stappenbeck TS, Matkovich SJ, McDaniel ML. A novel strategy to increase the proliferative potential of adult human beta-cells while maintaining their differentiated phenotype. PLoS One, 2013 Jun, 8(6): e66131. PMCID: 3680388.
Kimple ME, Keller MP, Rabaglia MR, Pasker RL, Neuman JC, Truchan NA, Brar HK, Attie AD. Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion. Diabetes, 2013 Jun, 62(6): 1904-12. PMCID: 3661627.
Loganathan G, Graham ML, Radosevich DM, Soltani SM, Tiwari M, Anazawa T, Papas KK, Sutherland DE, Hering BJ, Balamurugan AN. Factors affecting transplant outcomes in diabetic nude mice receiving human, porcine, and nonhuman primate islets: analysis of 335 transplantations. Transplantation, 2013 Jun, 95(12): 1439-47. PMCID: 3721976.
MacDonald MJ, Longacre MJ, Warner TF, Thonpho A. High level of ATP citrate lyase expression in human and rat pancreatic islets. Horm Metab Res, 2013 May, 45(5): 391-3. PMCID: 3923498.
Pedraza E, Brady AC, Fraker CA, Molano RD, Sukert S, Berman DM, Kenyon NS, Pileggi A, Ricordi C, Stabler CL. Macroporous three-dimensional PDMS scaffolds for extrahepatic islet transplantation. Cell Transplant, 2013 May, 22(7): 1123-35. PMCID: 4429907.
Rohatgi N, Aly H, Marshall CA, McDonald WG, Kletzien RF, Colca JR, McDaniel ML. Novel insulin sensitizer modulates nutrient sensing pathways and maintains beta-cell phenotype in human islets. PLoS One, 2013 May, 8(5): e62012. PMCID: 3641131.
Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The fractalkine/CX3CR1 system regulates beta cell function and insulin secretion. Cell, 2013 Apr, 153(2): 413-25. PMCID: 3717389.
MacDonald MJ, Langberg EC, Tibell A, Sabat G, Kendrick MA, Szweda LI, Ostenson CG. Identification of ATP synthase as a lipid peroxide protein adduct in pancreatic islets from humans with and without type 2 diabetes mellitus. J Clin Endocrinol Metab, 2013 Apr, 98(4): E727-31. PMCID: 3615212.
Zhang Y, Zhen W, Maechler P, Liu D. Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic beta-cell survival and function via CREB. J Nutr Biochem, 2013 Apr, 24(4): 638-46. PMCID: 3654796.
Bramswig NC, Everett LJ, Schug J, Dorrell C, Liu C, Luo Y, Streeter PR, Naji A, Grompe M, Kaestner KH. Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming. J Clin Invest, 2013 Mar, 123(3): 1275-84. PMCID: 3582140.
Kalwat MA, Yoder SM, Wang Z, Thurmond DC. A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic beta cells. Biochem Pharmacol, 2013 Mar, 85(6): 808-16. PMCID: 3578113.
Luo JZ, Xiong F, Al-Homsi AS, Ricordi C, Luo L. Allogeneic bone marrow cocultured with human islets significantly improves islet survival and function in vivo. Transplantation, 2013 Mar, 95(6): 801-9. PMCID: 3604119.
Mueller KR, Balamurugan AN, Cline GW, Pongratz RL, Hooper RL, Weegman BP, Kitzmann JP, Taylor MJ, Graham ML, Schuurman HJ, Papas KK. Differences in glucose-stimulated insulin secretion in vitro of islets from human, nonhuman primate, and porcine origin. Xenotransplantation, 2013 Mar, 20(2): 75-81. PMCID: 4145818.
Wang P, Schuetz C, Ross A, Dai G, Markmann JF, Moore A. Immune rejection after pancreatic islet cell transplantation: in vivo dual contrast-enhanced MR imaging in a mouse model. Radiology, 2013 Mar, 266(3): 822-30. PMCID: 3579171.
Wang Y, Liu J, Liu C, Naji A, Stoffers DA. MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic beta-cells. Diabetes, 2013 Mar, 62(3): 887-95. PMCID: 3581216.
Brooks-Worrell BM, Palmer JP. Attenuation of islet-specific T cell responses is associated with C-peptide improvement in autoimmune type 2 diabetes patients. Clin Exp Immunol, 2013 Feb, 171(2): 164-70. PMCID: 3573287.
El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep, 2013 Feb, 3(2): 401-10. PMCID: 3655439.
Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A. Regulation of glucagon secretion in normal and diabetic human islets by gamma-hydroxybutyrate and glycine. J Biol Chem, 2013 Feb, 288(6): 3938-51. PMCID: 3567647.
Liu S, Kilic G, Meyers MS, Navarro G, Wang Y, Oberholzer J, Mauvais-Jarvis F. Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia, 2013 Feb, 56(2): 370-81. PMCID: 3536964.
Nishiki Y, Adewola A, Hatanaka M, Templin AT, Maier B, Mirmira RG. Translational control of inducible nitric oxide synthase by p38 MAPK in islet beta-cells. Mol Endocrinol, 2013 Feb, 27(2): 336-49. PMCID: 3683810.
Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death. J Biol Chem, 2013 Jan, 288(4): 2428-40. PMCID: 3554912.
Klein D, Misawa R, Bravo-Egana V, Vargas N, Rosero S, Piroso J, Ichii H, Umland O, Zhijie J, Tsinoremas N, Ricordi C, Inverardi L, Dominguez-Bendala J, Pastori RL. MicroRNA expression in alpha and beta cells of human pancreatic islets. PLoS One, 2013 Jan Epub, 8(1): e55064. PMCID: 3558471.
Taylor-Fishwick DA, Weaver JR, Grzesik W, Chakrabarti S, Green-Mitchell S, Imai Y, Kuhn N, Nadler JL. Production and function of IL-12 in islets and beta cells. Diabetologia, 2013 Jan, 56(1): 126-35. PMCID: 3651896.
2012 (38)
Airavaara M, Pletnikova O, Doyle ME, Zhang YE, Troncoso JC, Liu QR. Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. J Biol Chem 2011;286(52):45093-102. [PubMed Abstract]
Amyot J, Semache M, Ferdaoussi M, Fontes G, Poitout V. Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-kappaB signalling. PLoS One. 2012;7(4):e36200. [PubMed Abstract]
Bone RN, Icyuz M, Zhang Y, Zhang Y, Cui W, Wang H, Peng JB, Matthews QL, Siegal GP, Wu H 2012 Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts beta-cell survival and proliferation differentially in vitro and in vivo. Islets 4:366-378 [PubMed Abstract]
Brehm MA, Powers AC, Shultz LD, Greiner DL 2012 Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice. Cold Spring Harbor perspectives in medicine 2:a007757. [PubMed Abstract]
Dai C, Brissova M, Hang Y, Thompson C, Poffenberger G, Shostak A, Chen Z, Stein R, Powers AC. Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia 2012;55(3):707-18. [PubMed Abstract]
Farmer K, Williams SJ, Novikova L, Ramachandran K, Rawal S, Blagg BS, Dobrowsky R, Stehno-Bittel L 2012 KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability. Exp Diabetes Res 2012:671673 [PubMed Abstract]
El Muayed M, Raja MR, Zhang X, MacRenaris KW, Bhatt S, Chen X, Urbanek M, O'Halloran TV, Lowe WL, Jr. 2012 Accumulation of cadmium in insulin-producing beta cells. Islets 4:405-416 [PubMed Abstract]
Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK. Neonatal beta cell development in mice and humans is regulated by calcineurin/NFAT. Dev Cell 2012;23(1):21-34. [PubMed Abstract]
Harris PE, Leibel RL: Neurofunctional imaging of beta-cell dynamics. Diabetes Obes Metab 2012, 14 Suppl 3:91-100. [PubMed Abstract]
Kim J, Breunig MJ, Escalante LE, Bhatia N, Denu RA, Dollar BA, Stein AP, Hanson SE, Naderi N, Radek J, Haughy D, Bloom DD, Assadi-Porter FM, Hematti P 2012 Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets. Cytotherapy 14:925-935 [PubMed Abstract]
Kondegowda NG, Mozar A, Chin C, Otero A, Garcia-Ocana A, Vasavada RC. Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling. Diabetologia. Jun 2012;55(6):1721-1732. [PubMed Abstract]
Kyriazis, G. A.; Soundarapandian, M. M.; Tyrberg, B. Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A 109(8):E524-532; 2012. [PubMed Abstract]
Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocana A, Scott DK. ChREBP mediates glucose-stimulated pancreatic beta-cell proliferation. Diabetes 2012;61(8):2004-15. [PubMed Abstract]
Oh E, Kalwat MA, Kim MJ, Verhage M, Thurmond DC. Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms. J Biol Chem 2012;287(31):25821-33. [PubMed Abstract]
Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH. Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets. Mol Endocrinol. 2012;26(9):1590-1602. [PubMed Abstract]
Rodriguez-Diaz R, Dando R, Huang YA, Berggren PO, Roper SD, Caicedo A. Real-time detection of acetylcholine release from the human endocrine pancreas. Nat Protoc. 2012;7(6):1015-1023. [PubMed Abstract]
Schrimpe-Rutledge AC, Fontes G, Gritsenko MA, Norbeck AD, Anderson DJ, Waters KM, Adkins JN, Smith RD, Poitout V, Metz TO. Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics. J Proteome Res 2012;11(7):3520-32. [PubMed Abstract]
Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel RL, Harris PE 2012 Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro. Mol Endocrinol 26:1757-1772. [PubMed Abstract]
Stephens SB, Schisler JC, Hohmeier HE, An J, Sun AY, Pitt GS, Newgard CB. A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet beta-cell survival and function. Cell Metab 2012;16(1):33-43. [PubMed Abstract]
Takane KK, Kleinberger JW, Salim FG, Fiaschi-Taesch NM, Stewart AF. Regulated and reversible induction of adult human beta-cell replication. Diabetes 2012;61(2):418-24. [PubMed Abstract]
van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO 2012 Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLoS One 7:e52181. [PubMed Abstract]
Velmurugan, K.; Balamurugan, A. N.; Loganathan, G.; Ahmad, A.; Hering, B. J.; Pugazhenthi, S. Antiapoptotic actions of exendin-4 against hypoxia and cytokines are augmented by CREB. Endocrinology 153(3):1116-1128; 2012. [PubMed Abstract]
Vernier S, Chiu A, Schober J, Weber T, Nguyen P, Luer M, McPherson T, Wanda PE, Marshall CA, Rohatgi N, McDaniel ML, Greenberg AS, Kwon G 2012 beta-cell metabolic alterations under chronic nutrient overload in rat and human islets. Islets 4:379-392 [PubMed Abstract]
Wang P, Yigit MV, Ran C, Ross A, Wei L, Dai G, Medarova Z, Moore A: A theranostic small interfering RNA nanoprobe protects pancreatic islet grafts from adoptively transferred immune rejection. Diabetes 2012, 61:3247-3254. [PubMed Abstract]
Weaver JR, Holman TR, Imai Y, Jadhav A, Kenyon V, Maloney DJ, Nadler JL, Rai G, Simeonov A, Taylor-Fishwick DA. Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Mol Cell Endocrinol 2012;358(1):88-95. [PubMed Abstract]
Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK. A human islet cell culture system for high-throughput screening. J Biomol Screen 2012;17(4):509-18. [PubMed Abstract]
Williams SJ, Schwasinger-Schmidt T, Zamierowski D, Stehno-Bittel L 2012 Diffusion into human islets is limited to molecules below 10 kDa. Tissue & cell 44:332-341 [PubMed Abstract]
Arifin DR, Manek S, Call E, Arepally A, Bulte JW. Microcapsules with intrinsic barium radiopacity for immunoprotection and X-ray/CT imaging of pancreatic islet cells. Biomaterials. Jun 2012;33(18):4681-4689. [PubMed Abstract]
Avgoustiniatos ES, Scott WE, 3rd, Suszynski TM, Schuurman HJ, Nelson RA, Rozak PR, Mueller KR, Balamurugan AN, Ansite JD, Fraga DW, Friberg AS, Wildey GM, Tanaka T, Lyons CA, Sutherland DE, Hering BJ, Papas KK 2012 Supplements in human islet culture: human serum albumin is inferior to fetal bovine serum. Cell Transplant 21:2805-2814. [PubMed Abstract]
Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B, Oberholzer J, Odorico JS, Garfinkel MR, Levy M, Pattou F, Berney T, Secchi A, Messinger S, Senior PA, Maffi P, Posselt A, Stock PG, Kaufman DB, Luo X, Kandeel F, Cagliero E, Turgeon NA, Witkowski P, Naji A, O'Connell PJ, Greenbaum C, Kudva YC, Brayman KL, Aull MJ, Larsen C, Kay TW, Fernandez LA, Vantyghem MC, Bellin M, Shapiro AM 2012 Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care 35:1436-1445 [PubMed Abstract]
Cechin SR, Perez-Alvarez I, Fenjves E, Molano RD, Pileggi A, Berggren PO, Ricordi C, Pastori RL 2012 Anti-inflammatory properties of exenatide in human pancreatic islets. Cell Transplant 21:633-648 [PubMed Abstract]
Doliba NM, Qin W, Najafi H, Liu C, Buettger CW, Sotiris J, Collins HW, Li C, Stanley CA, Wilson DF, Grimsby J, Sarabu R, Naji A, Matschinsky FM 2012 Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics. Am J Physiol Endocrinol Metab 302:E87-E102 [PubMed Abstract]
Iglesias I, Valiente L, Shiang KD, Ichii H, Kandeel F, Al-Abdullah IH 2012 The effects of digestion enzymes on islet viability and cellular composition. Cell Transplant 21:649-655 [PubMed Abstract]
Jeon J, Leibiger I, Moede T, Walter B, Faul C, Maiguel D, Villarreal R, Guzman J, Berggren PO, Mundel P, Ricordi C, Merscher-Gomez S, Fornoni A. Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells. J Biol Chem 2012;287(34):28932-42. [PubMed Abstract]
Kaddis JS, Hanson MS, Cravens J, Qian D, Olack B, Antler M, Papas KK, Iglesias I, Barbaro B, Fernandez L, Powers AC, Niland JC 2012 Standardized Transportation of Human Islets: An Islet Cell Resource Center Study of More Than 2,000 Shipments. Cell Transplant. [PubMed Abstract]
Misawa R, Ricordi C, Miki A, Barker S, Molano RD, Khan A, Miyagawa S, Inverardi L, Alejandro R, Pileggi A, Ichii H 2012 Evaluation of viable beta-cell mass is useful for selecting collagenase for human islet isolation: comparison of collagenase NB1 and liberase HI. Cell Transplant 21:39-47 [PubMed Abstract]
Qi M, Morch Y, Lacik I, Formo K, Marchese E, Wang Y, Danielson KK, Kinzer K, Wang S, Barbaro B, Kollarikova G, Chorvat D, Jr., Hunkeler D, Skjak-Braek G, Oberholzer J, Strand BL 2012 Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+ and Ba2+. Xenotransplantation 19:355-36 [PubMed Abstract]
Shu, L., Zien, K., Gutjahr, G., Oberholzer, J., Pattou, F., Kerr-Conte, J., & Maedler, K. 2012. TCF7L2 promotes beta cell regeneration in human and mouse pancreas. Diabetologia. 55(12), 3296-307. PMID: 22945304. [PubMed Abstract]
Weaver, J.R., Holman, T.R., Imai, Y., Jadhav, A., Kenyon, V., Maloney, D.J., Nadler, J.L., Rai, G., Simeonov, A., & Taylor-Fishwick, D.A. (2012). Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Mol Cell Endocrinol. 358(1), 88-95. PMID: 22502743. [PubMed Abstract]
2011 (47)
Anazawa, T.; Matsumoto, S.; Yonekawa, Y.; Loganathan, G.; Wilhelm, J. J.; Soltani, S. M.; Papas, K. K.; Sutherland, D. E.; Hering, B. J.; Balamurugan, A. N. Prediction of pancreatic tissue densities by an analytical test gradient system before purification maximizes human islet recovery for islet autotransplantation/allotransplantation. Transplantation 91(5):508-514; 2011. [PubMed Abstract]
Asari S, Itakura S, Rawson J, Ito T, Todorov I, Nair I, Shintaku J, Liu CP, Kandeel F, Mullen YS. Mesenchymal Stem Cells Facilitate Mixed Hematopoietic Chimerism Induction and Prevent Onset of Diabetes in Nonobese Diabetic Mice. Pancreas 2011. [PubMed Abstract]
Barnett BP, Ruiz-Cabello J, Hota P, Liddell R, Walczak P, Howland V, Chacko VP, Kraitchman DL, Arepally A, Bulte JW. Fluorocapsules for improved function, immunoprotection, and visualization of cellular therapeutics with MR, US, and CT imaging. Radiology 2011;258(1):182-91. [PubMed Abstract]
Barnett BP, Ruiz-Cabello J, Hota P, Ouwerkerk R, Shamblott MJ, Lauzon C, Walczak P, Gilson WD, Chacko VP, Kraitchman DL, Arepally A, Bulte JW. Use of perfluorocarbon nanoparticles for non-invasive multimodal cell tracking of human pancreatic islets. Contrast Media Mol Imaging 2011;6(4):251-9. [PubMed Abstract]
Bar-Nur, O., Russ, H.A., Efrat, S., & Benvenisty, N. 2011. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell. 9(1), 17-23. PMID: 21726830. [PubMed Abstract]
Bentsi-Barnes K, Doyle ME, Abad D, Kandeel F, Al-Abdullah I. Detailed protocol for evaluation of dynamic perifusion of human islets to assess beta-cell function. Islets 2011;3(5):284-90. [PubMed Abstract]
Costes S, Huang CJ, Gurlo T, Daval M, Matveyenko AV, Rizza RA, Butler AE, Butler PC. beta-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes 2011;60(1):227-38. [PubMed Abstract]
Feng Y, Guan XM, Li J, Metzger JM, Zhu Y, Juhl K, Zhang BB, Thornberry NA, Reitman ML, Zhou YP. Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species. Endocrinology 2011;152(11):4106-15. [PubMed Abstract]
Diiorio P, Jurczyk A, Yang C, Racki WJ, Brehm MA, Atkinson MA, Powers AC, Shultz LD, Greiner DL, Bortell R. Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rgammanull Ins2Akita mice. Pancreas 2011;40(7):1147-9. [PubMed Abstract]
Dorrell C, Schug J, Lin CF, Canaday PS, Fox AJ, Smirnova O, Bonnah R, Streeter PR, Stoeckert CJ, Jr., Kaestner KH, Grompe M. Transcriptomes of the major human pancreatic cell types. Diabetologia 2011;54(11):2832-44. [PubMed Abstract]
Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD. Humanized mice for the study of type 1 and type 2 diabetes. Ann N Y Acad Sci 2011;1245:55-8. [PubMed Abstract]
Karslioglu E, Kleinberger JW, Salim FG, Cox AE, Takane KK, Scott DK, Stewart AF. cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. Mol Endocrinol 2011;25(10):1760-72. [PubMed Abstract]
Li D, Chen S, Bellomo EA, Tarasov AI, Kaut C, Rutter GA, Li WH 2011 Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR). Proc Natl Acad Sci U S A 108:21063-21068 [PubMed Abstract]
Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL. Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model. Mol Pharm 2011;8(3):767-73. [PubMed Abstract]
MacDonald MJ, Longacre MJ, Stoker SW, Kendrick M, Thonpho A, Brown LJ, Hasan NM, Jitrapakdee S, Fukao T, Hanson MS, Fernandez LA, Odorico J. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. J Biol Chem 2011;286(21):18383-96. [PubMed Abstract]
Ohtsubo K, Chen MZ, Olefsky JM, Marth JD. Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat Med 2011;17(9):1067-75. [PubMed Abstract]
Stein J, Milewski WM, Hara M, Steiner DF, Dey A. GSK-3 inactivation or depletion promotes beta-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets 2011;3(1):21-34. [PubMed Abstract]
Syed I, Kyathanahalli CN, Jayaram B, Govind S, Rhodes CJ, Kowluru RA, Kowluru A. Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes 2011;60(11):2843-52 [PubMed Abstract]
Tiano JP, Delghingaro-Augusto V, Le May C, Liu S, Kaw MK, Khuder SS, Latour MG, Bhatt SA, Korach KS, Najjar SM, Prentki M, Mauvais-Jarvis F 2011 Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents beta cell failure in rodent models of type 2 diabetes. J Clin Invest 121:3331-3342 [PubMed Abstract]
Virostko J, Henske J, Vinet L, Lamprianou S, Dai C, Radhika A, Baldwin RM, Ansari MS, Hefti F, Skovronsky D, Kung HF, Herrera PL, Peterson TE, Meda P, Powers AC. Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands. Proc Natl Acad Sci U S A 2011;108(51):20719-24. [PubMed Abstract]
Wang Z, Oh E, Clapp DW, Chernoff J, Thurmond DC. Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem 2011;286(48):41359-67. [PubMed Abstract]
Wiseman DA, Kalwat MA, Thurmond DC. Stimulus-induced S-nitrosylation of Syntaxin 4 impacts insulin granule exocytosis. J Biol Chem 2011;286(18):16344-54. [PubMed Abstract]
Wu H, Lu W, Mahato RI. Mesenchymal stem cells as a gene delivery vehicle for successful islet transplantation. Pharm Res 2011;28(9):2098-109. [PubMed Abstract]
Wu H, Yoon AR, Li F, Yun CO, Mahato RI 2011 RGD peptide-modified adenovirus expressing hepatocyte growth factor and X-linked inhibitor of apoptosis improves islet transplantation. The journal of gene medicine 13:658-669 [PubMed Abstract]
Hall, K. K.; Gattas-Asfura, K. M.; Stabler, C. L. Microencapsulation of islets within alginate/poly(ethylene glycol) gels cross-linked via Staudinger ligation. Acta Biomater 7(2):614-624; 2011. [PubMed Abstract]
Huising MO, Pilbrow AP, Matsumoto M, van der Meulen T, Park H, Vaughan JM, Lee S, Vale WW. Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2alpha in MIN6 insulinoma cells and rodent islets. Endocrinology 2011;152(1):138-50. [PubMed Abstract]
Hirsch D, Odorico J, Radke N, Hanson M, Danobeitia JS, Hullett D, Alejandro R, Ricordi C, Fernandez LA. Correction of insulin sensitivity and glucose disposal after pancreatic islet transplantation: preliminary results. Diabetes Obes Metab 2010;12(11):994-1003. [PubMed Abstract]
Kim W, Doyle ME, Liu Z, Lao Q, Shin YK, Carlson OD, Kim HS, Thomas S, Napora JK, Lee EK, Moaddel R, Wang Y, Maudsley S, Martin B, Kulkarni RN, Egan JM. Cannabinoids inhibit insulin receptor signaling in pancreatic beta-cells. Diabetes 2011;60(4):1198-209. [PubMed Abstract]
Lee SH, Hao E, Levine F, Itkin-Ansari P. Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic beta-cells. Islets 2011;3(6):358-66. [PubMed Abstract]
Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano LC, Zou B, O'Donnell CP, Stewart AF, Garcia-Ocana A, Alonso LC. Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. Diabetologia 2011;54(3):572-82. [PubMed Abstract]
Loganathan G, Dawra RK, Pugazhenthi S, Guo Z, Soltani SM, Wiseman A, Sanders MA, Papas KK, Velayutham K, Saluja AK, Sutherland DE, Hering BJ, Balamurugan AN 2011 Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of alpha-1 antitrypsin treatment. Transplantation 92:1222-1230 [PubMed Abstract]
Luo JZ, Xiong F, Al-Homsi AS, Roy T, Luo LG. Human BM stem cells initiate angiogenesis in human islets in vitro. Bone Marrow Transplant 2011;46(8):1128-37. [PubMed Abstract]
Lu W, Li F, Mahato RI. Poly(ethylene glycol)-block-poly(2-methyl-2-benzoxycarbonyl-propylene carbonate) micelles for rapamycin delivery: in vitro characterization and biodistribution. J Pharm Sci 2011;100(6):2418-29. [PubMed Abstract]
Medina MC, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, Pileggi A, Hernandez A, Edlund H, Bianco AC. The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology 2011;152(10):3717-27. [PubMed Abstract]
Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocana A. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes 2011;60(2):525-36. [PubMed Abstract]
Omori K, Mitsuhashi M, Ishiyama K, Nair I, Rawson J, Todorov I, Kandeel F, Mullen Y 2011 mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-alpha-induced islet damage in humans. Diabetologia 54:2056-2066 [PubMed Abstract]
Rodriguez-Diaz R, Abdulreda MH, Formoso AL, Gans I, Ricordi C, Berggren PO, Caicedo A 2011 Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab 14:45-54 [PubMed Abstract]
Rodriguez-Diaz R, Dando R, Jacques-Silva MC, Fachado A, Molina J, Abdulreda MH, Ricordi C, Roper SD, Berggren PO, Caicedo A 2011 Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans. Nat Med 17:888-892 [PubMed Abstract]
Shaw KL, Pais E, Ge S, Hardee C, Skelton D, Hollis RP, Crooks GM, Kohn DB. Lentiviral vectors with amplified beta cell-specific gene expression. Gene Ther 2009;16(8):998-1008. [PubMed Abstract]
Stein J, Milewski WM, Hara M, Steiner DF, Dey A. GSK-3 inactivation or depletion promotes beta-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets 2011;3(1):21-34. [PubMed Abstract]
Tian L, Gao J, Weng G, Yi H, Tian B, O'Brien TD, Guo Z. Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts. Transpl Int 2011;24(8):856-64. [PubMed Abstract]
Tschen SI, Georgia S, Dhawan S, Bhushan A. Skp2 is required for incretin hormone-mediated beta-cell proliferation. Mol Endocrinol 2011;25(12):2134-43. [PubMed Abstract]
Wang Y, Paushter D, Wang S, Barbaro B, Harvat T, Danielson KK, Kinzer K, Zhang L, Qi M, Oberholzer J 2011 Highly purified versus filtered crude collagenase: comparable human islet isolation outcomes. Cell Transplant 20:1817-1825 [PubMed Abstract]
Wang P, Yigit MV, Medarova Z, Wei L, Dai G, Schuetz C, Moore A. Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation. Diabetes 2011;60(2):565-71. [PubMed Abstract]
Wiseman DA, Kalwat MA, Thurmond DC. Stimulus-induced S-nitrosylation of Syntaxin 4 impacts insulin granule exocytosis. J Biol Chem 2011;286(18):16344-54. [PubMed Abstract]
Xu Z, Wei G, Chepelev I, Zhao K, Felsenfeld G. Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription. Nat Struct Mol Biol 2011;18(3):372-8. [PubMed Abstract]
Zhang Y, Liu D. Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. Eur J Pharmacol 2011;670(1):325-32. [PubMed Abstract]
2010 (63)
Balamurugan AN, Breite AG, Anazawa T, Loganathan G, Wilhelm JJ, Papas KK, Dwulet FE, Francis E, McCarthy RC, Hering BJ: Successful human islet islolation and transplantation indicating the importance of class 1 collagenase and collagen degradation activity assay. Transplantation Vol 89 Issue 8 pp 954-961 2010 Apr 27 [PubMed Abstract]
Bhandare R, Schug J, Le Lay J, et al. Genome-wide analysis of histone modifications in human pancreatic islets. Genome Res. Apr;20(4):428-433. [PubMed Abstract]
Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD. Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes 2010;59(9):2265-70. [PubMed Abstract]
Chepurny OG, Kelley GG, Dzhura I, et al. PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans. Am J Physiol Endocrinol Metab. Mar;298(3):E622-633. [PubMed Abstract]
Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia ME, Sperger JM, Fernandez LA, Yandell BS, Keller MP, Wang IM, Schadt EE, Attie AD. FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol Endocrinol 2010;24(9):1822-34. [PubMed Abstract]
Faleck DM, Ali K, Roat R, Graham MJ, Crooke RM, Battisti R, Garcia E, Ahima RS, Imai Y. Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets. Am J Physiol Endocrinol Metab 2010;299(2):E249-57. [PubMed Abstract]
Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF. Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes 2010;59(8):1926-36. [PubMed Abstract]
Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sorensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S A 2010;107(34):15099-104. [PubMed Abstract]
Fotino C, Ricordi C, Lauriola V, Alejandro R, Pileggi A. Bone marrow-derived stem cell transplantation for the treatment of insulin-dependent diabetes. Rev Diabet Stud 2010;7(2):144-57. [PubMed Abstract]
Fornoni A, Jeon J, Varona Santos J, et al. Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release. Diabetes. Jan;59(1):190-199. [PubMed Abstract]
Fu Z, Zhang W, Zhen W, et al. Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology. Jul;151(7):3026-3037. [PubMed Abstract]
Gonzalez-Pertusa JA, Dube J, Valle SR, et al. Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis. Endocrinology. Apr;151(4):1487-1498. [PubMed Abstract]
Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocana A, Vasavada RC. Parathyroid hormone-related protein enhances human ss-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes 2010;59(12):3131-8. [PubMed Abstract]
Heyduk E, Moxley MM, Salvatori A, Corbett JA, Heyduk T. Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets. Diabetes 2010;59(10):2360-5. [PubMed Abstract]
Huang CJ, Gurlo T, Haataja L, et al. Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. J Biol Chem. Jan 1;285(1):339-348. [PubMed Abstract]
Huising MO, van der Meulen T, Vaughan JM, Matsumoto M, Donaldson CJ, Park H, Billestrup N, Vale WW: CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. PNAS 2010 Jan 12; 912-917, Vol. 107, No. 2 [PubMed Abstract]
Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala US. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem 2010;285(29):22426-36. [PubMed Abstract]
Humphrey RK, Yu SM, Flores LE, Jhala US. Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases. J Biol Chem 2010;285(5):3406-16. [PubMed Abstract]
Jacques-Silva MC, Correa-Medina M, Cabrera O, Rodriguez-Diaz R, Makeeva N, Fachado A, Diez J, Berman DM, Kenyon NS, Ricordi C, Pileggi A, Molano RD, Berggren PO, Caicedo A. ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell. Proc Natl Acad Sci U S A 2010;107(14):6465-70. [PubMed Abstract]
Kaddis JS, Danobeitia JS, Niland JC, Stiller T, Fernandez LA.Am J Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes. Transplant. 2010 Mar;10(3):646-56. doi: 10.1111/j.1600-6143.2009.02962.x. Epub 2010 Jan 5.PMID: 20055802 [PubMed Abstract]
Kennedy J, Katsuta H, Jung M-H, Marselli L, Goldfine AB, Balis UJ, Sgroi D, Bonner-Weir S, Weir GC. Protective Unfolded Protein Response in Human Pancreatic Beta Cells Transplanted into Mice. PLoS ONE;5(6):e11211. [PubMed Abstract]
Kim BJ, Zhou J, Martin B, Carlson OD, Maudsley S, Greig NH, Mattson MP, Ladenheim EE, Wustner J, Turner A, Sadeghi H, Egan JM. Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides. J Pharmacol Exp Ther 2010;334(3):682-92. [PubMed Abstract]
Kiselyuk A, Farber-Katz S, Cohen T, Lee S-H, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F: Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen. J Biomol Screen 15(6); 2010 Published online Jun 14, 2010 [PubMed Abstract]
Kissler HJ, Niland JC, Olack B, et al. Validation of methodologies for quantifying isolated human islets: an Islet Cell Resources study. Clin Transplant. Mar 1;24(2):236-242. [PubMed Abstract]
Lee SH, Itkin-Ansari P, Levine F. CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells. Aging. 2010;2(11):785-790. [PubMed Abstract]
Leech CA, Dzhura I, Chepurny OG, Schwede F, Genieser HG, Holz GG. Facilitation of ss-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac. Islets 2010;2(2):72-81. [PubMed Abstract]
Leibiger IB, Brismar K, Berggren PO: Novel aspects on pancreatic beta-cell signal-transduction. Biochemical and Biophysical Research Communications 396 (2010) 111-115 [PubMed Abstract]
Leitao CB, Bernetti K, Tharavanij T, et al. Lipotoxicity and decreased islet graft survival. Diabetes Care. Mar;33(3):658-660. [PubMed Abstract]
Leitao CB, Froud T, Cure P, Tharavanij T, Pileggi A, Ricordi C, Alejandro R. Nonalbumin proteinuria in islet transplant recipients. Cell Transplant 2010;19(1):119-25. [PubMed Abstract]
Leoni L, Serai SD, Haque ME, Magin RL, Roman BB. Functional MRI characterization of isolated human islet activation. NMR Biomed 2010;23(10):1158-65. [PubMed Abstract]
Leoni L, Roman BB. MR imaging of pancreatic islets: tracking isolation, transplantation and function. Curr Pharm Des. May 2010;16(14):1582-1594. [PubMed Abstract]
Liew CW, Bochenski J, Kawamori D, et al. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest. Aug 2 2010;120(8):2876-2888. [PubMed Abstract]
Liu S, Navarro G, Mauvais-Jarvis F. Androgen excess produces systemic oxidative stress and predisposes to beta-cell failure in female mice. PLoS One 2010;5(6):e11302. [PubMed Abstract]
Loganathan G, Dawra RK, Pugazhenthi S, Wiseman AC, Sanders MA, Saluja AK, Sutherland DE, Hering BJ, Balamurugan AN. Culture of impure human islet fractions in the presence of alpha-1 antitrypsin prevents insulin cleavage and improves islet recovery. Transplant Proc 2010;42(6):2055-7. [PubMed Abstract]
Mita A, Ricordi C, Messinger S, Miki A, Misawa R, Barker S, Molano RD, Haertter R, Khan A, Miyagawa S, Pileggi A, Inverardi L, Alejandro R, Hering BJ, Ichii H. Antiproinflammatory effects of iodixanol (OptiPrep)-based density gradient purification on human islet preparations. Cell Transplant 2010;19(12):1537-46. [PubMed Abstract]
Mondal AK, Das SK, Baldini G, et al. Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans. J Clin Endocrinol Metab. Mar;95(3):1450-1457. [PubMed Abstract]
Nduaguibe CC, Bentsi-Barnes K, Mullen Y, Kandeel F, Al-Abdullah I. Serine protease inhibitors suppress pancreatic endogenous proteases and modulate bacterial neutral proteases. Islets 2010;2(3):200-6. [PubMed Abstract]
Niland JC, Stiller T, Cravens J, Sowinski J, Kaddis J, Qian D 2010 Effectiveness of a web-based automated cell distribution system. Cell Transplant 19:1133-1142 [PubMed Abstract]
Ogihara T, Chuang JC, Vestermark GL, et al. Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem. Feb 19;285(8):5392-5404. [PubMed Abstract]
Omori K, Mitsuhashi M, Todorov I, et al. Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation. Transplantation. Jan 27 2010;89(2):146-154. [PubMed Abstract]
Omori K, Todorov I, Shintaku J, et al. P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery. Pancreas. May;39(4):436-443. [PubMed Abstract]
Ortqvist E, Brooks-Worrell B, Lynch K, Radtke J, Bekris LM, Kockum I, Agardh CD, Cilio CM, Lethagen AL, Persson B, Lernmark A, Reichow J, Oak S, Palmer JP, Hampe CS. Changes in GAD65Ab-specific antiidiotypic antibody levels correlate with changes in C-peptide levels and progression to islet cell autoimmunity. J Clin Endocrinol Metab 2010;95(11):E310-8. [PubMed Abstract]
Papas KK, Colton CK, Qipo A, Wu H, Nelson RA, Hering BJ, Weir GC, Koulmanda M. J Prediction of marginal mass required for successful islet transplantation. Invest Surg. 2010 Feb;23(1):28-34. [PubMed Abstract]  [Full Text]
Pisania A, Weir GC, O'Neil JJ, Omer A, Tchipashvili V, Lei J, Colton CK, Bonner-Weir S. Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest 2010;90(11):1661-75. [PubMed Abstract]
Papas KK, Colton CK, Qipo A, Wu H, Nelson RA, Hering BJ, Weir GC, Koulmanda M. Prediction of marginal mass required for successful islet transplantation. J Invest Surg, 2010 Feb, 23(1): 28-34. PMCID: 3786417.
Pisania A, Papas KK, Powers DE, Rappel MJ, Omer A, Bonner-Weir S, Weir GC, Colton CK. Enumeration of islets by nuclei counting and light microscopic analysis. Lab Invest 2010;90(11):1676-86. [PubMed Abstract]
Potter KJ, Abedini A, Marek P, et al. Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts. Proc Natl Acad Sci U S A. Mar 2;107(9):4305-4310. [PubMed Abstract]
Pugazhenthi U, Velmurugan K, Tran A, Mahaffey G, Pugazhenthi S: Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients. Diabetologia Published online: 16July 2010 [PubMed Abstract]
Rink JS, McMahon KM, Chen X, Mirkin CA, Thaxton CS, Kaufman DB. Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticles. Surgery. Aug;148(2):335-345. [PubMed Abstract]
Ritzel, R. A.; Jayasinghe, S.; Hansen, J. B.; Sturis, J.; Langen, R.; Butler, P. C. Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity. Regul Pept 165(2-3):158-162; 2010. [PubMed Abstract]
Rohatgi N, Remedi MS, Kwon G, Pappan KL, Marshall CA, McDaniel ML. Therapeutic strategies to increase human β-cell growth and proliferation by regulating mTOR and GSK-3/β-catenin pathways. The Open Endocrinology Journal, 2010, 4, 40-54. [PubMed Abstract]
Sabek, O.M., Ferrati, S., Fraga, D.W., Sih, J., Zabre, E.V., Fine, D.H., Ferrari, M., Gaber, A.O., & Grattoni, A. (2013). Characterization of a nanogland for the autotransplantation of human pancreatic islets. Lab Chip. 13(18), 3675-88. PMID: 23884326. [PubMed Abstract]
Scott WE, 3rd, O'Brien TD, Ferrer-Fabrega J, Avgoustiniatos ES, Weegman BP, Anazawa T, Matsumoto S, Kirchner VA, Rizzari MD, Murtaugh MP, Suszynski TM, Aasheim T, Kidder LS, Hammer BE, Stone SG, Tempelman LA, Sutherland DE, Hering BJ, Papas KK. Persufflation improves pancreas preservation when compared with the two-layer method. Transplant Proc 2010;42(6):2016-9. [PubMed Abstract]
Scott WE, 3rd, Weegman BP, Ferrer-Fabrega J, Stein SA, Anazawa T, Kirchner VA, Rizzari MD, Stone J, Matsumoto S, Hammer BE, Balamurugan AN, Kidder LS, Suszynski TM, Avgoustiniatos ES, Stone SG, Tempelman LA, Sutherland DE, Hering BJ, Papas KK. Pancreas oxygen persufflation increases ATP levels as shown by nuclear magnetic resonance. Transplant Proc 2010;42(6):2011-5. [PubMed Abstract]
Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De Leon DD, Naji A, Kushner JA, Stoffers DA. Calcineurin signaling regulates human islet {beta}-cell survival. J Biol Chem 2010;285(51):40050-9. [PubMed Abstract]
Stitzel ML, Sethupathy P, Pearson DS, Chines PS, Song L, Erdos MR, Welch R, Parker SC, Boyle AP, Scott LJ, Margulies EH, Boehnke M, Furey TS, Crawford GE, Collins FS. Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab 2010;12(5):443-55. [PubMed Abstract]
Todorov I, Nair I, Avakian-Mansoorian A, Rawson J, Omori K, Ito T, Valiente L, Iglesias-Meza I, Orr C, Shiang KD, Ferreri K, Al-Abdullah IH, Mullen Y, Kandeel F. Quantitative assessment of beta-cell apoptosis and cell composition of isolated, undisrupted human islets by laser scanning cytometry. Transplantation 2010;90(8):836-42. [PubMed Abstract]
Trikha, S., & Jeremic, A.M. (2013). Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cells. PLoS One. 8(9), e73080. PMCID: PMC3760900. [PubMed Abstract]
Tsunekawa S, Demozay D, Briaud I, McCuaig J, Accili D, Stein R, Rhodes CJ. FoxO feedback control of basal IRS-2 expression in pancreatic beta-cells is distinct from that in hepatocytes. Diabetes 2011;60(11):2883-91. [PubMed Abstract]
Vendrame F, Pileggi A, Laughlin E, et al. Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes. Apr;59(4):947-957. [PubMed Abstract]
Wang Z, Thurmond DC. Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion. J Biol Chem. Feb 26;285(9):6186-6197. [PubMed Abstract]
Wu H, Panakanti R, Li F, Mahato RI 2010 XIAP gene expression protects beta-cells and human islets from apoptotic cell death. Mol Pharm 7:1655-1666 [PubMed Abstract]
Yamamoto T, Mita A, Ricordi C, et al. Prolactin supplementation to culture medium improves beta-cell survival. Transplantation. Jun 15;89(11):1328-1335. [PubMed Abstract]
Zhang Z, Liew CW, Handy DE, et al. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. Faseb J. May;24(5):1497-1505. [PubMed Abstract]
Zhao J, Schug J, Li M, Kaestner KH, Grant SFA: Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo. Diabetologia (2010) 53:2340-2346; Published online: 2010 July17. [PubMed Abstract]
 
2009 (36)
Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S: Induction of antioxidant enzymes by curcumin and its analogues in human islets: Implications in transplantation. Pancreas Vol 00, (00) Published Ahead of Print, 2 Feb 2009 [PubMed Abstract]
Bedrood S, Jayasinghe S, Sieburth D, et al. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. Nov 10 2009;48(44):10568-10576. [PubMed Abstract]
Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, Kim SK: Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes & Dev. 2009 Apr 15; 23(8):975-85 [PubMed Abstract]
Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, and Pastori RL: MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expr Patterns. 2009 Apr;9 (4):193-9. Epub 2008 Dec 24. [PubMed Abstract]
Dhawan S, Tschen SI, Bhushan A: Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 2009 Apr 15;23(8):906-11. [PubMed Abstract]
Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, Harb G, Selk K, Cozar-Castellano I, Stewart AF: Survey of the Human Pancreatic Beta Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human Beta Cell Replication and Function in Vivo. Diabetes, 2009 Apr;58(4):882-93. Epub 2009 Jan 9. [PubMed Abstract]
Glas R, Sauter NS, Schulthess FT, Shu L, Oberholzer J, Maedler K: Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival. Diabetologia 2009 Aug;52(8):1579-88. Epub 2009 Apr 25 [PubMed Abstract]
Hughes KJ, Chambers KT, Meares GP, Corbett JA. Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated beta-cells that is associated with irreversible DNA damage. Am J Physiol Endocrinol Metab 2009;297(5):E1187-96. [PubMed Abstract]
Huang J, Levitsky LL, Rhoads DB: Novel P2 Promoter-Derived HNF4α Isoforms with Different N-Terminus Generated by Alternate Exon Insertion. Exp Cell Res. 2009 Apr 15;315(7):1200-11 [PubMed Abstract]
Ichii H, Ricordi C: Current status of islet cell transplantation. J Hepatobiliary Pancreat Surg. 2009;16(2):101-12. Epub 2008 Dec 26 [PubMed Abstract]
Kaddis J, Olack B, Sowinski J, Cravens J, Contreras J, Niland J. Human Pancreatic Islets and Diabetes Research. JAMA. 2009;301(15):1580-1587 [PubMed Abstract]
Kharouta M, Miller K, Kim A, et al. No mantle formation in rodent islets -- the prototype of islet revisited. Diabetes Res Clin Pract. Sep 2009;85(3):252-257. [PubMed Abstract]
Kuroda A, Rauch TA, Todorov I, et al. Insulin gene expression is regulated by DNA methylation. PLoS One. 2009;4(9):e6953. [PubMed Abstract]
Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P: Human [beta]-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies. Transplantation. 2009 Apr 15;87 (7):983-91 [PubMed Abstract]
Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML. Both Glycogen Synthase Kinase-3 (GSK-3) and Mammalian Target of Rapamycin (mTOR) Pathways Contribute to DNA Synthesis, Cell Cycle Progression and Proliferation in Human Islets. 2009 Mar;58(3):663-72. Epub 2008 Dec 10 [PubMed Abstract]
Liu S, Le May C, Wong WP, Ward RD, Clegg DJ, Marcelli M, Korach KS, Mauvais-Jarvis F: Importance of extranuclear estrogen receptor-{alpha} and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes. 2009 Jul 8. [Epub ahead of print] [PubMed Abstract]
Liu S, Okada T, Assmann A, et al. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009;4(11):e7983. [PubMed Abstract]
Liu S, Mauvais-Jarvis F: Rapid, nongenomic estrogen actions protect pancreatic islet survival. Islets 1:3, 23-25; November/December 2009 [PubMed Abstract]
MacDonald MJ, Longacre MJ, Kendrick MA. Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells. Arch Biochem Biophys. Aug 15 2009;488(2):100-104. [PubMed Abstract]
Miki A, Ricordi C, Messinger S, et al. Toward improving human islet isolation from younger donors: rescue purification is efficient for trapped islets. Cell Transplant. 2009;18(1):13-22. [PubMed Abstract]
Mohammed JS, Wang Y, Harvat TA, Oberholzer J, Eddington DT: Microfluidic device for multimodal characterization of pancreatic islets. Lab Chip. 2009 Jan 7;9(1):97-106. Epub 2008 Oct 21. [PubMed Abstract]
Mulla CM, Geras-Raaka E, Raaka BM, Gershengorn MC: High levels of thyrotropin-releasing hormone receptors activate programmed cell death in human pancreatic precursors. Pancreas 2009 Mar. 38(2)197-202. [PubMed Abstract]
Mutskov V, Felsenfeld G. The human insulin gene is part of a large open chromatin domain specific for human islets. Proc Natl Acad Sci U S A. Oct 13 2009;106(41):17419-17424. [PubMed Abstract]
Panakanti R, Mahato RI: Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation. Pharm Res. 2009 Mar;26(3):587-96. Epub 2008 Nov 12. [PubMed Abstract]
Panakanti R, Mahato RI: Bipartite Vector Encoding hVEGF and hIL-1Ra for Ex Vivo Transduction into Human Islets. Mol Pharm. 2009 Jan-Feb; 6(1): 274-84. [PubMed Abstract]
Papas KK, Suszynski TM, Colton CK. Islet assessment for transplantation. Curr Opin Organ Transplant. Dec 2009;14(6):674-682. [PubMed Abstract]
Prokunina-Olsson L, Welch C, Hansson O, et al. Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet. Oct 15 2009;18(20):3795-3804. [PubMed Abstract]
Qi M, Barbaro B, Wang S, Wang Y, Hansen M, Oberholzer J: Human pancreatic islet isolation: Part I: digestion and collection of pancreatic tissue. J Vis Exp. 2009 May 26;(27). pii: 1125. doi: 10.3791/1125 [PubMed Abstract]
Qi M, Barbaro B, Wang S, Wang Y, Hansen M, Oberholzer J: Human pancreatic islet isolation: Part II: purification and culture of human islets. J Vis Exp. 2009 May 26;(27). pii: 1343. doi: 10.3791/1343 [PubMed Abstract]
Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S: Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic Beta cells. PLoS One. 2009 Jul 29;4(7):e6417 [PubMed Abstract]
Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S: Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signaling in human islets and in a mouse beta cell line. Diabetologia. 2009 Jun;52(6):1092-101. Epub 2009 Apr 3. [PubMed Abstract]
Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC, Maedler K: CXCL10 impairs β-cell function and viability in diabetes through TLR4 signaling. Cell Metab. 2009 Feb;9(2):125-39. [PubMed Abstract]
Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K: Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet. 2009 Jul 1;18(13):2388-99. Epub 2009 Apr 21 [PubMed Abstract]
Wilson LM, Wong SH, Yu N, Geras-Raaka E, Raaka BM, Gershengorn MC. Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. Stem Cells. Nov 2009;27(11):2703-2711. [PubMed Abstract]
Yu J, Steck AK, Babu S, Yu L, Miao D, McFann K, Hutton J, Eisenbarth GS, Klingensmith G. Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes. J Clin Endocrinol Metab. 2009 Feb; 94(2):504-10. Epub 2008 Dec 2. [PubMed Abstract]
Zhang S, Carper MJ, Lei X, Cade WT, Yarasheski KE, Ramanadham S: Protease inhibitors used in the treatmentof HIV induce β-cell apoptosis via the mitochondrial pathway and compromise insulin secretion. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E925-35. Epub 2009 Feb 10 [PubMed Abstract]<
2008 (63)
Al-Abdullah IH, Bentsi-Barnes K, Valiente L, et al. Testing Combinations of Protease Inhibitor and Preservation Solution to Improve Islet Quality and Yield. Transplantation Proceedings 2008. 40, 390-392. [PubMed Abstract]
Alejandro R, Barton FB, Hering BJ, Wease S; Collaborative Islet Transplant Registry Investigators: 2008 Update from the Collaborative Islet Transplant Registry. Transplantation. 2008 Dec 27;86(12):1783-8 [PubMed Abstract]
Avgoustiniatos ES, Hering BJ, Rozak PR, Wilson JR, Tempelman LA, Balamurugan AN, Welch DP, Weegman BP, Suszynski TM and Papas KK: Commercially available gas-permeable cell culture bags may not prevent anoxia in cultured or shipped islets. Transplant Proc. 2008 Mar;40(2):395-400. [PubMed Abstract]
Bar Y, Russ HA, Knoller S, Ouziel-Yahalom L, Efrat S: HES-1 is involved in adaptation of adult human β-Cells to proliferation in vitro. Diabetes. 2008 Sep;57(9):2413-20. Epub 2008 Jul 3. [PubMed Abstract]
Bentsi-Barnes K, Kandeel F, Al-Abdullah IH. Evaluation of Human Islet- Specific Functional Quality Cultured on Different Gas- Permeable Membranes. Transplantation Proceedings 2008. 40, 401-402. [PubMed Abstract]
Boyd V, Cholewa OM, Papas KK. Limitations in the Use of Fluorescein Diacetate/Propidium Iodide (FDA/PI) and Cell Permeable Nucleic Acid Stains for Viability Measurements of Isolated Islets of Langerhans. Curr Trends Biotechnol Pharm 2008;2(2):66-84. [PubMed Abstract]
Bravo-Egana V, Rosero S, Molano RD, Pileggi A, Ricordi C, Domínguez-Bendala J, Pastori RL: Quantitative differential expression analysis reveals miR-7 as major islet microRNA. Biochem Biophys Res Commun 2008. 366(4):922-6. Epub 2007 Dec 18. [PubMed Abstract]
Brissova M, Powers AC. Revascularization of Transplanted Islets: Can It Be Improved? Diabetes 57: 2269, 2008. [PubMed Abstract]
Brun T, He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR: The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1. Hum Mol Genet 2008. 17(4):478-89. Epub 2007 Nov 7. [PubMed Abstract]
Cabrera O, Jacques-Silva MC, Speier S, Yang S-N, Kohler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO: Glutamate Is a Positive Autocrine Signal for Glucagon Release. Cell Metab 7, 545-554; Jun 2008. [PubMed Abstract]
Cabrera O, Jacques-Silva MC, Berman DM, Fachado A, Echeverri F, Poo R, Khan A, Kenyon NS, Ricordi C, Berggren PO, Caicedo A: Automated, high-throughput assays for evaluation of human pancreatic islet function. Cell Transplant. 2008;16(10):1039-48. [PubMed Abstract]
Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA: The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes. 2008 Jan; 57(1):124-32. [PubMed Abstract]
Cheng G, Zhu L, Mahato RI: Caspase-3 Gene Silencing for Inhibiting Apoptosis in Insulinoma Cells and Human Islets. Mol Pharm. 2008 Nov-Dec;5(6):1093-102. [PubMed Abstract]
Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF: Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. Diabetes, 2008 Nov;57(11):3056-68. Epub 2008 Jul 23 [PubMed Abstract]
Deshet N, Lupu-Meiri M, Espinoza I, Fili O, Shapira Y, Lupu R, Gershengorn MC, Oron Y: Plasminogen-induced aggregation of PANC-1 cells requires conversion to plasmin and is inhibited by endogenous plasminogen activator inhibitor-1. J. Cell. Physiol. 216: 632-639. 2008 [Wiley]
Dorrell C, Abraham SL, Lanxon-Cookson KM, Canaday PS, Streeter PR, Grompe M: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. Stem Cell Res. 2008 Sep;1(3):183-94. Epub 2008 May 8 [PubMed Abstract]
Efrat S: Ex-vivo Expansion of Adult Human Pancreatic Beta-Cells. Rev Diabet Stud. 2008 Summer;5(2):116-22. Epub 2008 Aug 10. [PubMed Abstract]
Evgenov NV, Pratt J, Pantazopoulos P, Moore A: Effects of Glucose Toxicity and Islet Purity on In Vivo Magnetic Resonance Imaging of Transplanted Pancreatic Islets. Transplantation 2008;85: 1091-1098. [PubMed Abstract]
Fornoni A, Pileggi A, Molano RD, Sanabria NY, Tejada T, Gonzalez-Quintana J, Ichii H, Inverardi L, Ricordi C, Pastori RL: Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation. Diabetologia 2008 Feb; 51(2): 298-308. Epub Dec 8. [PubMed Abstract]
Gangemi A, Salehi P, Hatipoglu B, Martellotto J, Barbaro B, Kuechle JB, Qi M, Wang Y, Pallan P, Owens C, Bui J, West D, Kaplan B, Benedetti E, Oberholzer J. Islet transplantation for brittle type 1 diabetes: the UIC protocol. Am J Transplant. 2008 Jun;8(6):1250-61. [PubMed Abstract]
Huang J, Karakucuk V, Levitsky LL and Rhoads DB. Expression of HNF4a variants in pancreatic islets and Ins-1 b cells. Diabetes Metab Res Rev 2008 [Epub ahead of print: June 17; DOI: 10.1002/dmrr.870] [PubMed Abstract]
Ichii H, Miki A, Yamamoto T, Molano RD, Barker S, Mita A, Rodriguez-Diaz R, Klein D, Pastori R, Alejandro R, Inverardi L, Pileggi A, Ricordi C: Characterization of pancreatic ductal cells in human islet preparations. Lab Invest. 2008 Sep 8. [Epub ahead of print]  [PubMed Abstract]
Iglesias I, Bentsi-Barnes K, Umeadi C, Brown L, Kandeel F, Al-Abdulla IH. Comprehensive Analysis of Human Pancreatic Islets Using Flow and Laser Scanning Cytometry. Transplantation Proceedings 2008. 40, 351-354 [PubMed Abstract]
Ikonomou L, Geras-Raaka E, Raaka BM, Gershengorn MC. Beta-catenin signaling in mesenchymal islet-derived precursor cells. Cell Proliferation 2008. 41:474. [PubMed Abstract]
Ito T, Omori K, Rawson J, Todorov I, Asari S, Kuroda A, Shintaku J, Itakura S, Ferreri K, Kandeel F, Mullen Y. Improvement of canine islet yield by donor pancreas infusion with a p38MAPK inhibitor. Transplantation. 2008 Jul 27; 86(2): 321-9. [PubMed Abstract]
Jayaraman S: A novel method for the detection of viable human pancreatic beta cells by flow cytometry using fluorophores that selectively detect labile zinc, mitochondrial membrane potential and protein thiols. Cytometry A. 2008 Jul;73(7):615-25.PMID: 18412218 [PubMed Abstract]
Jewell JL, Luo W, Oh E, Wang Z, Thurmond DC. Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4. J Biol Chem 2008. 283:10716-10726. PMID: 18285343 [Full text]
Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC: The mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3 null mouse. Diabetes. 2008 Jul 3. [PubMed Abstract]
Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG: Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells. J Physiol 2008. 586(5):1307-19. Epub 2008 Jan 17. [PubMed Abstract]
King M, Pearson T, Rossini AA, Shultz LD, Greiner DL: Humanized mice for the study of type 1 diabetes and beta cell function. Ann NY Acad Sci 2008 Dec; 1150: 46-53 [PubMed Abstract]
King M, Pearson T, Shultz LD, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL 2 receptor gamma chain gene. Clinical Immunology 2008. 126:303-314. [PubMed Abstract]
Klein D, Timoneri F, Ichii H, Ricordi C, Pastori RL. CD40 Activation in Human Pancreatic Islets and Ductal Cells. Diabetologia. 2008 Jul 26. [PubMed Abstract]
Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD. Overexpression of pre-pro-cholecystokinin stimulates {beta}-cell proliferation in mouse and human islets with retention of islet function. Mol Endocrinol. 2008 Oct 9. [PubMed Abstract]
Lee S-H, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P: Islet specific Wnt activation in human type II diabetes. Exp Diabetes Res. 2008; 728-763. [PubMed Abstract]
Leitao CB, Tharavanij T, Cure P, Pileggi A, Baidal DA, Ricordi C, Alejandro R. Restoration of Hypoglycemia Awareness after Islet Transplantation. Diabetes Care. 2008 Aug 12. [PubMed Abstract]
Li F, Mahato RI: iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis. Mol Pharm 2008 May-Jun;5(3):407-17. Epub 2008 Jan 25. [PubMed Abstract]
Li N, Zhao D, Kirschbaum M, Zhang C, Lin CL, Todorov I, Kandeel F, Forman S, Zeng D. HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen. Proc Natl Acad Sci U S A 105, 4796-4801, 2008. [PubMed Abstract]
Li Y, Maedler K, Shu L, Haataja L. UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. PLoS ONE. 2008 Jan 2; 3(1):e1397. [PubMed Abstract]
Linetsky E, Ricordi C. Regulatory challenges in manufacturing of pancreatic islets. Transplant Proc. 2008 Mar;40(2):424-6. [PubMed Abstract]
Luo L, Fang X, Ricordi C, Luo J: Human Islet Longevity: A New Approach with Allogeneic Bone Marrow. 2008 Diabetes 57:Suppl.1 1596-P, A446
Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC. Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab. 2008 Mar;93(3):1046-53. [PubMed Abstract]
Mathew JM, Blomberg B, Ricordi C, Esquenazi V, Miller J. Evaluation of the tolerogenic effects of donor bone marrow cells using a severe combined immunodeficient mouse-human islet transplant model. Hum Immunol. 2008 Aug 11 [Epub ahead of print]. [PubMed Abstract]
Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H. Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 2008 Jun;51(6):978-88. [PubMed Abstract]
Miki A, Ricordi C, Yamamoto T, Mita A, Barker S, Khan A, Alejandro R, Ichii H: Effect of Human Islet Rescue Gradient Purification on Islet Yield and Fractional Beta Cell Viability. Transplant Proc. 2008 Mar;40(2):360-1. [PubMed Abstract]
Parnaud G, Bosco D, Berney T, Pattou F, Kerr-Conte J, Donath MY, Bruun C, Mandrup-Poulsen T, Billestrup N, Halban PA. Proliferation of sorted human and rat beta cells. Diabetologia. 2008 Jan;51(1):91-100. [PubMed Abstract]
Pearson T, Shultz LD, Leif J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL: A new immunodeficient hyperglycemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia. 2008 Aug;51(8):1449-56. Epub 2008 Jun 19. [PubMed Abstract]
Poitout V, Robertson RP. Glucolipotoxicity: Fuel excess and beta-cell dysfunction. Endocr Rev 2008. 29(3):351-66. Epub 2007 Nov 29 [PubMed Abstract]
Powers AC. Insulin Therapy versus Cell-Based Therapy for Type 1 Diabetes - What is ahead? Nature Clinical Practice Endocrinology & Metabolism, in press, 2008 [PubMed Abstract]
Robertson RP. Metabolic measures of islet function and mass after islet transplantation. In. Islet transplantation and beta-cell replacement therapy. Eds. Shaw J, Ricordi C, Lakey J, Shapiro J. In press.
Robertson RP. Beta-cell replacement: pancreas and islet transplantation. In Type 1 diabetes in adults: principle and practice. Eds. Jabbour S, Hirsch I, Garg S, Stephens EZ, Goldstein BJ, Riddle M. 2008 In press
Rozak PR, Weegman B, Avgoustiniatos ES, Wilson JR, Welch DP, Hering BJ, Papas KK: Devices and methods for maintenance of temperature and pressure during islet shipment. Transplant Proc. 2008 Mar;40(2):407-10. [PubMed Abstract]
Sakuma Y, Ricordi C, Miki A, Yamamoto T, Pileggi A, Khan A, Alejandro R, Inverardi L, Ichii H: Factors That Affect Human Islet Isolation. Transplant Proc. 2008 Mar;40(2):343-5. [PubMed Abstract]
Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes. 2008 Mar;57(3):645-53. Epub 2007 Dec 10. PMID: 18071026 Full Text Diabetes
Stanojevic V, Habener JF, Holz GG, Leech CA: Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells. Biochem Biophys Res Commun 2008. 368(3):614-9. Epub 2008 Feb 1. [PubMed Abstract]
Suckow AT, Comoletti D, Waldrop MA, Mosedale M, Egodage S, Taylor P, Chessler SD. Expression of neurexin, neuroligin and their cytoplasmic binding partners in the pancreatic {beta}-cells and the involvement of neuroligin in insulin secretion. Endocrinology 149 (12): 6006-6017, Dec. 2008 [PubMed Abstract]
Suszynski TM, Wildey GM, Falde EJ, Cline GW, Maynard KS, Ko N, Sotiris J, Naji A, Hering BJ, Papas KK: The ATP/DNA Ratio Is a Better Indicator of Islet Cell Viability Than the ADP/ATP Ratio. Transplant Proc. 2008 Mar;40(2):346-50. [PubMed Abstract]
Sweet IR, Gilbert M, Scott S, Todorov I, Jensen R, Nair I, Al-Abdullah I, Rawson J, Kandeel F, Ferreri K: Glucose-stimulated increment in oxygen consumption rate as a standardized test of human islet quality. Am J Transplant. 2008 Jan;8(1):183-92. Epub 2007 Nov 12. [PubMed Abstract]
Umeadi C, Bentsi-Barnes K, Kandeel F, Al-Abdullah IH. Endogenous Pancreatic Protease Activity and Methods for Impeding Their Function. Transplantation Proceedings 2008. 40, 355-357 [PubMed Abstract]
Umeadi C, Kandeel F, Al-Abdullah IH: Ulinastatin Is a Novel Protease Inhibitor and Neutral Protease Activator. Transplant Proc. 2008 Mar;40(2):387-9. [PubMed Abstract]>
Varona-Santos JL, Pileggi A, Molano RD, Sanabria NY, Ijaz A, Atsushi M, Ichii H, Pastori RL, Inverardi L, Ricordi C, Fornoni A. c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets. Diabetologia. 2008 Dec;51(12):2271-80. Epub 2008 Oct 14. [PubMed Abstract]
Vlad G, D'Agati VD, Zhang QY, Liu Z, Ho EK, Mohanakumar T, Hardy MA, Cortesini R, Suciu-Foca N. ILT3-FC Suppresses T Cell Responses to Allogeneic Human Islet Transplants in HU-NOD/SCID Mice. Diabetes 2008; Apr 16. [Epub ahead of print] PMID: 18420485 [PubMed Abstract]
Xu BY, Yu Y, Al-Abdullah IH, Kandeel F, Hering B, Wright Jr. JR: Long-Term Survival and Function of Intraportal Porcine and Human Islet Xenografts in Nondiabetic Nude Mice. Transplant Proc. 2008 Mar; 40(2):584-6. PMID: 18374135 [PubMed Abstract]
Yamamoto T, Ricordi C, Mita A, Miki A, Sakuma Y, Molano RD, Fornoni A, Pileggi A, Inverardi L, Ichii H: Beta-Cell Specific Cytoprotection by Prolactin on Human Islets. Transplant Proc. 2008 Mar;40(2):382-3. [PubMed Abstract]
2007 (39)
Ai C, Todorov I, Slovak ML, Digiusto D, Forman SJ, Shih CC. Human Marrow-Derived Mesodermal Progenitor Cells Generate Insulin-Secreting Islet-Like Clusters In Vivo. Stem Cells Dev 16, 757-770, 2007. [PubMed Abstract]
Barbaro B, Salehi P, Wang Y; Qi M, Gangemi A, Kuechle J, Hansen MA, Romagnoli T, Avila J, Benedetti E, Mage R, Oberholzer J: Improved Human Pancreatic Islet Purification With the Refined UIC-UB Density Gradient. Transplantation. 84(9):1200-1203, November 15, 2007. [PubMed Abstract]
Barnett BP, Arepally A, Karmarkar PV, Qian D, Gilson WD, Walczak P, Howland V, Lawler L, Lauzon C, Stuber M, Kraitchman DL, Bulte JW. Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells. Nat Med. 2007 Sep;13(8):986-991. Epub 2007 Jul 29.[PubMed Abstract]
Bertuzzi F, Ricordi C: Prediction of clinical outcome in islet allotransplantation. Diabetes Care. 2007 Feb;30(2):410-7. [PubMed Abstract]
Chow R, Michael D, Xiong W, Drain P: Pulsatile Insulin Secretion Imaged at the Single-Vesicle Level in Human Pancreatic Beta Cells. Microscopy and Microanalysis 13 (Suppl 2): 322-323. Aug 2007. [ProQuest Abstract]
Clark GO, Yochem RL, Axelman J, Sheets TP, Kaczorowski DJ, Shamblott MJ: Glucose responsive insulin production from human embryonic germ (EG) cell derivatives. Biochem Biophys Res Commun. 2007 May 11;356(3):587-93. [PubMed Abstract]
Davani B, Ikonomou L, Raaka BM, Geras-Raaks E, Morton RA, Marcus-Samuels B, Gershengorn MC. Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo. Stem Cells 2007. 25:3215. PMID: 17901402 Full Text - Stem Cells
De Paula D, Bentley MV, Mahato RI: Effect of iNOS and NF-kappaB gene silencing on beta-cell survival and function. J Drug Target. 2007 Jun;15(5):358-69. [PubMed Abstract]
Faradji RN, Monroy K, Messinger S, Pileggi A, Froud T, Baidal DA, Cure PE, Ricordi C, Luzi L, Alejandro R. Simple measures to monitor beta-cell mass and assess islet graft dysfunction. Am J Transplant. 2007 Feb;7(2): 303-8. Epub 2006 Dec 6.[PubMed Abstract]
Fisher JS, Lakey JRT, Mirbolooki M, Robertson RP, Marsh CL. Pancreas and Islet Transplantation. In: Comprehensive Clinical Nephrology, 3rd Edition, p. 1131-1145. eds Feehally, J, Floege J, Johnson RJ, 2007.
Ichii H, Wang X, Messinger S, Alvarez A, Fraker C, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C. Shipment of human islets for transplantation. Am J Transplant. 2007 Apr;7(4):1010-20. [PubMed Abstract]
Itakura S, Asari S, Rawson J, Ito T, Todorov I, Liu CP, Sasaki N, Kandeel F, Mullen Y: Mesenchymal stem cells facilitate the induction of mixed hematopoietic chimerism and islet allograft tolerance without GVHD in the rat. Am J Transplant 2007 Feb;7 (2):336-46. PMID: 17283484 [PubMed Abstract]
Jia X, Cheng K, Mahato RI. Coexpression of vascular endothelial growth factor and interleukin-1 receptor antagonist for improved human islet survival and function. Mol Pharm 2007. Mar-Apr;4(2);199-207. [PubMed Abstract]
Kayali AG, Flores LE, Lopez AD, Kutlu B, Baetge E, Kitamura R, Hao E, Beattie GM, Hayek A. Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells. Diabetes. 2007 Mar;56(3):703-8. [PubMed Abstract]
Ke B, Oh E, Thurmond DC. Doc2beta is a novel Munc18c- interacting partner and positive effector of syntaxin 4-mediated exocytosis. J Biol Chem. 2007 Jun 4. [PubMed Abstract]
Luo L, Badiavas E, Colvin G, Luo J, Maizel A: Allogeneic Bone Marrow Support Of Human Pancreatic Islet's β-Cells. Biochem Biophys Res Commun. Volume 361, Issue 4, 5 Oct 2007, Pages 859-864. PMID: 17686461
Michael DJ, Xiong W, Geng X, Drain P, Chow RH: Human insulin vesicle dynamics during pulsatile secretion. Diabetes. 2007 May;56(5):1277-88. [PubMed Abstract]
Mutskov V, Raaka BM, Felsenfeld G, Gershengorn MC. The Human Insulin Gene Displays Transcriptionally Active Epigenetic Marks in Islet-derived Mesenchymal Precursor Cells in the Absence of Insulin Expression. Stem Cells 2007 Sep 27; [PubMed Abstract]
Omori K, Shintaku J, Rawson J, Todorov I, Nair I, Al-Abdullah I, Higgins LS, Medicherla S, Kandeel F, Mullen Y. P38 mitogen activated protein kinase inhibitor (p38IH) improved the quality of cultured human islets. Xenotransplantation, Volume 14, Issue 5 (p 420).
Omori K, Valiente L, Orr C, Rawson J, Ferreri K, Todorov I, Al-Abdullah I, Medicherla S, Potter AA, Shreiner GF, Kandeel F, Mullen Y: Improvement of human islet cryopreservation by a p38 MAPK inhibitor. Am J Transplant 7:1224-1232, May 2007 [PubMed Abstract]
Papas KK, Colton CK, Nelson RA, Rozak PR, Avgoustiniatos ES, Scott WE 3rd, Wildey GM, Pisania A, Weir GC, Hering BJ. Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant. 2007 Mar;7(3):707-13. Epub 2007 Jan 4. [PubMed Abstract]
Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth. Diabetes 56(2):311-9, 2007. [PubMed Abstract]
Qian D, Kaddis J, Niland J. A matching algorithm for the distribution of human pancreatic islets. Comput. Statist. Data Anal. (2007), doi: 10.1013/j.csda.2007.02.030 [PubMed Abstract]
Rawson J, Kandeel F, Mullen Y: Evaluation of three mouse models for in vivo quality assessment of human islets: euglycemic NOD scid, multidoes- STZ diabetic NOD scid and AKITA rag-/- mice. Xenotransplantation, Volume 14, Issue 5 (p 500).
Rickels MR, Kamoun M, Kearns J, Markmann JF, Naji A. Evidence for Allograft Rejection in an Islet Transplant Recipient and Effect on {beta}-Cell Secretory Capacity. J Clin Endocrinol Metab. 2007 Jul;92(7):2410-4. Epub 2007 May 8. [PubMed Abstract]
Rickels MR, Schutta MH, Mueller R, Kapoor S, Markmann JF, Naji A, Teff KL. Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients. J Clin Endocrinol Metab. 2007 Mar;92(3):873-9. Epub 2006 Dec 27. [PubMed Abstract]
Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler PC. Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. Diabetes. 2007 Jan;56(1):65-71. [PubMed Abstract]
Robertson RP. Estimation of beta-cell mass by metabolic tests: necessary, but how sufficient? Diabetes. 2007 Oct;56(10):2420-4. Epub 2007 Jul 2. Full Text - Diabetes
Robertson, RP. Beta Cell Replacement: Pancreas and Islet Transplantation. Type 1 Diabetes in Adults: Principles and Practice. p. 247-261. Jabbour S, Stephens EA, Hirsch I, Goldstein BJ, Garg S, Riddle M, eds. Informa Healthcare, plc. 2007.
Robertson RP, Sutherland DER. Beta and alpha cell metabolic outcomes after successful pancreas and islet transplantation at the University of Minnesota. Clin Transpl 2007.
Sarkar SA, Gunter J, Bouchard R, Reusch JE, Wiseman A, Gill RG, Hutton JC, Pugazhenthi S. Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia. 2007 Aug;50(8):1649-59. Epub 2007 Jun 26. [PubMed Abstract]
Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes 2007 Jan. 56(1):72-9. [PubMed Abstract]
Todorov I, Nair I, Omori K, Ito T, Rawson J, Valiente L, Al-Abdullah I, Ferreri K, Mullen Y, Kandeel F: Evaluation of cell composition and beta cell apoptosis in isolated undissociated pancreatic islets by laser scanning cytometry. Xenotransplantation, Volume 14, Issue 5 (p 499).
Tonooka N, Oseid E, Zhou H, Harmon J, Robertson RP. Glutathione peroxidase protein expression and activity in human islets isolated for transplantation. Clin Transplant 21:767-772, 2007. [PubMed Abstract]
Tracy S, Drescher KM. Coxsackievirus infections and NOD mice: relevant models of protection from, and induction of, type 1 diabetes. Ann N Y Acad Sci. 2007 Apr;1103:143-51. Epub 2007 Mar 21. Review. [PubMed Abstract]
Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocana A. Protein Kinase C-{zeta} Activation Markedly Enhances {beta}-Cell Proliferation: An Essential Role in Growth Factor-Mediated {beta}-Cell Mitogenesis. Diabetes. 2007 Aug 8; [Epub ahead of print] [PubMed Abstract]
Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC: The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5. [PubMed Abstract]
Yamamoto T, Ricordi C, Messinger S, et al: Deterioration and Variability of Highly Purified Collagenase Blends Used in Clinical Islet Isolation. Transplantation 2007. Volume 84(8), 27 October 2007, pp 997-1002. [PubMed Abstract]
Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir S. Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes. 2007 Jul;56(7):1802-9. Epub 2007 May 1. [PubMed Abstract]
2006 (37)
Barbé-Tuana FM, Klein D, Ichii H, Berman DM, Coffey L, Kenyon NS, Ricordi C, Pastori RL: CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets. Diabetes 55:2437-2445, 2006 [PubMed Abstract]
Barnett BP, Kraitchman DL, Lauzon C, Magee CA, Walczak P, Gilson WD, Arepally A, Bulte JWM: Radiopaque alginate microcapsules for x-ray visualization and Immunoprotection of cellular therapeutics. Molecular Pharmaceutics Vol. 3, No. 5, 531-538 2006 Aug 05. [PubMed Abstract]
Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A: The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc.Natl.Acad.Sci.U.S.A 103:2334-2339, 2006 [PubMed Abstract]
Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocana A, Vasavada R, Stewart AF. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev. 2006 Jun;27(4):356-70. Epub 2006 Apr 25. Review. [PubMed Abstract]
Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore A. In vivo imaging of islet transplantation. Nat Med. 2006 Jan;12(1):144-8. Epub 2005 Dec 25. [PubMed Abstract]
Evgenov NV, Medarova Z, Pratt J, Pantazopoulos P, Leyting S, Bonner-Weir S, Moore A: In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets. Diabetes 55: 2419-2428, 2006 [PubMed Abstract]
Gianani R, Putnam A, Still T, Yu L, Miao D, Gill RG, Beilke J, Supon P, Valentine A, Iveson A, Dunn S, Eisenbarth GS, Hutton J, Gottlieb P, Wiseman A: Initial results of screening of non - diabetic organ donors for expression of islet autoantibodies. J.Clin.Endocrinol.Metab 2006 May 91 (5):1855-61 Epub 2006 Feb 14. [PubMed Abstract]
Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med. 2006 Mar;12(3):310-6. Epub 2006 Feb 19. [PubMed Abstract]
Ichii H, Wang X, Messinger S, Alvarez A, Fraker C, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C. Improved human islet isolation using nicotinamide. Am J Transplant. 2006 Sep;6(9):2060-8. Epub 2006 Jul 6. [PubMed Abstract]
Ihm SH, Matsumoto I, Sawada T, Nakano M, Zhang HJ, Ansite JD, Sutherland DE, Hering BJ. Effect of donor age on function of isolated human islets. Diabetes 2006 May;55(5):1361-8. [PubMed Abstract]
Kaido T, Yebra M, Cirulli V, Rhodes C, Diaferia G, Montgomery AM. Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription. Diabetes 2006 Oct;55(10):2723-9. [PubMed Abstract]
Kang G, Chepurney OG, Malester B, Rindler MJ, Relumann H, Bos JL, Schwede F, Coetzee WA, Holz GG: cAMP Sensor Epac As A Determinant of ATP-Sensitive Potassium Channel Activity in Human Pancreatic Beta Cells And Rat INS-1 Cells. J Physiol 573.3: 595-609, 2006 [PubMed Abstract]
Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL: Noninvasive imaging of islet grafts using positron-emission tomography. PNAS 103: 11294-11299, 2006 [PubMed Abstract]
Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. Long-term monitoring of transplanted islets using positron emission tomography. Mol Ther. 2006 Dec;14(6):851-6. Epub 2006 Sep 18. [PubMed Abstract]
Medarova Z, Evgenov NV, Dai G, Bonner-Weir S, Moore A. In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc. 2006;1(1):429-35. [PubMed Abstract]
Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1317-24. Epub 2006 Jul 18. [PubMed Abstract]
Meier JJ, Ritzel RA, Maedler K, Gurlo T, Butler PC. Increased vulnerability of newly forming beta cells to cytokine-induced cell death. Diabetologia. 2006 Jan;49(1):83-9. Epub 2005 Dec 2. [PubMed Abstract]
Metz TO, Jacobs JM, Gritsenko MA, Fontes G, Qian WJ, Camp DG 2nd, Poitout V, Smith RD. Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS. J Proteome Res. 2006 Dec;5(12):3345-54. [PubMed Abstract]
Michael DJ, Ritzel RA, Haataja L, Chow RH: Pancreatic {beta}-Cells Secrete Insulin in Fast- and Slow-Release Forms. Diabetes 55: 600-607, 2006 [PubMed Abstract]
Mohanakumar T, Narayanan K, Desai N, Ramachandran S, Shenoy S, Jendrisak M, Susskind BM, Olack B, Benshoff N, Phelan DL, Brennan DC, Fernandez LA, Odorico JS, Polonsky KS: A significant role for histocompatibility in human islet transplantation. Transplantation Jul 27;82(2):180-7, 2006 [PubMed Abstract]
Narang AS, Sabek O, Gaber AO, Mahato RI: Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function. Pharm Res. 2006 Sep;23(9):1970-82. Epub 2006 Aug 12. [PubMed Abstract]
Ouziel-Yahalom L, Zalzman M, Anker-Kitai L, Knoller S, Bar Y, Glandt M, Herold K, Efrat S. Expansion and redifferentiation of adult human pancreatic islet cells. Biochem Biophys Res Commun. 2006 Mar 10;341(2):291-8. Epub 2006 Jan 19. [PubMed Abstract]
Poggioli R, Faradji RN, Ponte G, Betancourt A, Messinger S, Baidal DA, Froud T, Ricordi C, Alejandro R: Quality of life after islet transplantation. Am.J.Transplant 6:371-378, 2006 [PubMed Abstract]
Rickels MR, Naji A, Teff KL: Insulin Sensitivity, Glucose Effectiveness, and Free Fatty Acid Dynamics after Human Islet Transplantation for Type 1 Diabetes. J. Clin. Endocrinol. Metab. 91: 2138-2144, 2006 [PubMed Abstract]
Ritzel RA, Veldhuis JD, Butler PC. The mass, but not the frequency, of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure. Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E750-6. Epub 2005 Nov 8. [PubMed Abstract]
Robertson RP, Harmon JS. Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic beta cell. Free Rad Biol Med 2006 Jul 15; 41(2):177-84. [PubMed Abstract]
Robertson RP. Replacing Beta Cells in Diabetes. In Commentaries on Perspectives in Diabetes, Vol 1 (1988-1993), p. 212-217. Robertson RP, ed. American Diabetes Association. 2006.
Robertson, RP. What is successful islet transplantation in 2006? European Endocrine Disease 2006 Issue 2.
Robertson RP, Davis C, Larsen J, Stratta R, Sutherland DE; American Diabetes Association Position Statement. Pancreas and Islet Transplantation in Type 1 Diabetes Diabetes Care 29:35, 2006. Full Text - Diabetes
Sabek OM, Marshall DR, Penmetsa R, Scarborough O, Gaber AO. Examination of gene expression profile of functional human pancreatic islets after 2-week culture. Transplant Proc. 2006 Dec;38(10):3678-9. [PubMed Abstract]
Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS. Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet 2006 Apr;2(4):e51. Epub 2006 Apr 7 [PubMed Abstract]
Shanmugam N, Todorov IT, Nair I, Omori K, Reddy MA, Natarajan R. Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice. Diabetologia. 2006 Jan;49(1):100-7. Epub 2005 Dec 10. [PubMed Abstract]
Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR. International Multicenter Trial of Islet Transplantation in Type 1 Diabetes Using the Edmonton Protocol. N Engl J Med 355(13):1318-30. 2006. [PubMed Abstract]
Steer SA, Scarim AL, Chambers KT, Corbett JA. Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med 2006 Feb;3(2):e17. Epub 2005 Dec 20. [PubMed Abstract]
Todorov I, Omori K, Pascual M, Rawson J, Nair I, Valiente L, Vuong T, Matsuda T, Orr C, Ferreri K, Smith CV, Kandeel F, Mullen Y. Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation. Pancreas 2006 Mar;32(2):130-8. [PubMed Abstract]
Yang J, Wong RK, Park M, Wu J, Cook JR, York DA, Deng S, Markmann J, Naji A, Wolf BA, Gao Z: Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells. Diabetes 55:193-201, 2006 [PubMed Abstract]

Zhang G, Matsumoto S, Newman H, Strong DM, Robertson RP, Reems JA. Improve islet yields and quality when clinical grade pancreata are preserved by the two-layer method. Cell Tissue Bank 2006;7(3):195-201. [PubMed Abstract]
2005 (44)

Albisser AM, Alejandro R, Meneghini LF, Ricordi C: How good is your glucose control? Diabetes Technol.Ther. 7:863-875, 2005 [PubMed Abstract]
Albisser AM, Baidal D, Alejandro R, Ricordi C: Home blood glucose prediction: clinical feasibility and validation in islet cell transplantation candidates. Diabetologia 2005 Jul;48(7):1273-9. Epub 2005 Jun 3. [PubMed Abstract]
Bharat A, Benshoff N, Olack B, Ramachandran S, Desai NM, Mohanakumar T: Novel in vivo murine model to study islet potency: engraftment and function. Transplantation 79:1627-1630, 2005 [PubMed Abstract]
Brissova M, Fowler MJ, Nicholson WE, Chu A, Hirshberg B, Harlan DM, Powers AC: Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy. J. Histochem. Cytochem 53: 1087-1097, 2005 [PubMed Abstract]
Faradji RN, Monroy K, Cure P, Froud T, Baidal D, Pileggi A, Messinger S, Ricordi C, Alejandro R: C-peptide and glucose values in the peritransplant period after intraportal islet infusions in type 1 diabetes. Transplant Proc. 37:3433-3434, 2005 [PubMed Abstract]
Fowler M, Virostko J, Chen Z, Poffenberger G, Radhika A, Brissova M, Shiota M, Nicholson WE, Shi Y, Hirshberg B, Harlan DM, Jansen ED, Powers AC. Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation 2005 Apr 15;79(7):768-76 [PubMed Abstract]
Fraga DW, Gaber AO, Kotb M: Long-term culture and maintenance of human islets of Langerhans in memphis serum-free media. Methods Mol.Med. 107:303-311, 2005 [PubMed Abstract]
Froud T, Ricordi C, Baidal DA, Hafiz MM, Ponte G, Cure P, Pileggi A, Poggioli R, Ichii H, Khan A, Ferreira JV, Pugliese A, Esquenazi VV, Kenyon NS, Alejandro R: Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am.J.Transplant 5:2037-2046, 2005 [PubMed Abstract]
Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K: The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab 2:373-384, 2005 [PubMed Abstract]
Geiger MC, Ferreira JV, Hafiz MM, Froud T, Baidal DA, Meneghini LF, Ricordi C, Alejandro R: Evaluation of metabolic control using a continuous subcutaneous glucose monitoring system in patients with type 1 diabetes mellitus who achieved insulin independence after islet cell transplantation. Cell Transplant 14:77-84, 2005 [PubMed Abstract]
Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR: Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122:337-349, 2005 [PubMed Abstract]
Hafiz MM, Faradji RN, Froud T, Pileggi A, Baidal DA, Cure P, Ponte G, Poggioli R, Cornejo A, Messinger S, Ricordi C, Alejandro R: Immunosuppression and procedure-related complications in 26 patients with type 1 diabetes mellitus receiving allogeneic islet cell transplantation. Transplantation 80:1718-1728, 2005 [PubMed Abstract]
Han D, Leith J, Alejandro R, Bolton W, Ricordi C, Kenyon NS: Peripheral blood cytotoxic lymphocyte gene transcript levels differ in patients with long-term type 1 diabetes compared to normal controls. Cell Transplant 14:403-409, 2005 [PubMed Abstract]
Hering BJ: Achieving and maintaining insulin independence in human islet transplant recipients. Transplantation 79:1296-1297, 2005 [PubMed Abstract]
Hering BJ, Kandaswamy R, Ansite JD, Eckman PM, Nakano M, Sawada T, Matsumoto I, Ihm SH, Zhang HJ, Parkey J, Hunter DW, Sutherland DE: Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 293:830-835, 2005 [PubMed Abstract]
Ichii H, Inverardi L, Pileggi A, Molano RD, Cabrera O, Caicedo A, Messinger S, Kuroda Y, Berggren PO, Ricordi C: A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations. Am.J.Transplant 5:1635-1645, 2005 [PubMed Abstract]
Ichii H, Pileggi A, Molano RD, Baidal DA, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C: Rescue purification maximizes the use of human islet preparations for transplantation. Am.J.Transplant 5:21-30, 2005 [PubMed Abstract]
Ichii H, Pileggi A, Wang X, Khan A, Kuroda Y, Inverardi L, Alejandro R, Ricordi C: Pre-transplant assessment of cultured islets prior to clinical islet transplantation. American Journal of Transplantation. 5 (S11):790;2005
Jacobson PA, Green KG, Hering BJ: Mycophenolate mofetil in islet cell transplant: variable pharmacokinetics but good correlation between total and unbound concentrations. J.Clin.Pharmacol. 45:901-909, 2005 [PubMed Abstract]
Klein D, Barbe-Tuana F, Pugliese A, Ichii H, Garza D, Gonzalez M, Molano RD, Ricordi C, Pastori RL. A functional CD40 receptor is expressed in pancreatic beta cells. Diabetologia. 2005 Feb;48(2):268-76. Epub 2005 Feb 3. [PubMed Abstract]
Lechner A, Nolan AL, Blacken RA, Habener JF. Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun 2005 Feb 11;327(2):581-8 [PubMed Abstract]
Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC.: Activation of peroxisome proliferator-activated receptors-gamma (PPAR-gamma) by rosiglitazone protects human islet cells against human-islet amyloid polypeptide toxicity by a PI3 kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. Epub 2005 Oct 4. [PubMed Abstract]
Marshall D, Sabek O, Fraga D, Kotb M, Gaber AO: Examination of the molecular signature associated with islet dysfunction. Transplant Proc. 37:1311-1312, 2005 [PubMed Abstract]
Matsuda T, Omori K, Vuong T, Pascual M, Valiente L, Ferreri K, Todorov I, Kuroda Y, Smith CV, Kandeel F, Mullen Y. Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function. Am J Transplant 2005 Mar;5(3):484-93 [PubMed Abstract]
Matsuda T, Ferreri K, Todorov I, Duroda Y, Smith CV, Kandeel F, Mullen: Silymarin Protects Pancreatic ß-Cells against Cytokine-Mediated Toxicity: Implication of c-Jun NH2-Terminal Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Pathways. Endocrinology 146: 175-185 Jan 2005 [PubMed Abstract]
Mendoza V, Klein D, Ichii H, Ribeiro MM, Ricordi C, Hankeln T, Burmester T, Pastori RL: Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction. Transplant Proc. 37:237-240, 2005 [PubMed Abstract]
Narang AS, Thoma L, Miller DD, Mahato RI: Cationic lipids with increased DNA binding affinity for nonviral gene transfer in dividing and nondividing cells. Bioconjug Chem. 2005 Jan-Feb;16(1):156-68. [PubMed Abstract]
Nath DS, Hering BJ: Islet cells replacement therapy. Clin.Lab Med. 2005 Sep; 25(3):541-56 [PubMed Abstract]
Omori K, Valiente L, Orr C, Rawson J, Ferreri K, Todorov I, Medicherla S, Protter AA, Schreiner GF, Riggs AD, Kandeel F, Mullen Y. Inhibition of p38 mitogen-activated protein kinase protects human islets from cryoinjury and improves the yield, viability, and quality of frozen-thawed islets. Transplant Proc. 2005 Oct;37(8):3422-3.[PubMed Abstract]
Papas KK, Avgoustiniatos ES, Tempelman LA, Weir GC, Colton CK, Pisania A, Rappel MJ, Friberg AS, Bauer AC, Hering BJ: High-density culture of human islets on top of silicone rubber membranes. Transplant Proc. 37:3412-3414, 2005 [PubMed Abstract]
Papas KK, Hering BJ, Gunther L, Rappel MJ, Colton CK, Avgoustiniatos ES: Pancreas oxygenation is limited during preservation with the two-layer method. Transplant Proc. 37:3501-3504, 2005 [PubMed Abstract]
Poggioli R, Froud T, Baidal DA, Ferreira JV, Hafiz MM, Ricordi C, Gleich GJ, Alejandro R: Hypereosinophilia in an islet transplant recipient. Transplantation 79:853-854, 2005 [PubMed Abstract]
Rickels MR, Schutta MH, Markmann JF, Barker CF, Naji A, Teff KL: {beta}-Cell Function Following Human Islet Transplantation for Type 1 Diabetes. Diabetes 54:100-106, 2005 [PubMed Abstract]
Rickels MR, Schutta MH, Mueller R, Markmann JF, Barker CF, Naji A, Teff KL: Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes. Diabetes 54: 3205-3211, 2005 [PubMed Abstract]
Ricordi C, Inverardi L, Kenyon NS, Goss J, Bertuzzi F, Alejandro R: Requirements for success in clinical islet transplantation. Transplantation 79:1298-1300, 2005 [PubMed Abstract]
Robertson RP, Tanaka Y, Takahashi H, Tran POT, Harmon JS. Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic islets. Ann New York Acad Sci 2005 Jun;1043:513-20. [PubMed Abstract]
Sabek OM, Fraga DW, Minoru O, McClaren JL, Gaber AO: Assessment of human islet viability using various mouse models. Transplant Proc. 37:3415-3416, 2005 [PubMed Abstract]
Sabek OM, Marshall DR, Minoru O, Fraga DW, Gaber AO: OP-142 gene expression profile of nonfunctional human pancreatic islets: predictors of transplant failure? Transplant Proc. 37:3441-3443, 2005 [PubMed Abstract]
Sweet IR, Gilbert M, Jensen R, Sabek O, Fraga DW, Gaber AO, Reems J: Glucose stimulation of cytochrome C reduction and oxygen consumption as assessment of human islet quality. Transplantation 80:1003-1011, 2005 [PubMed Abstract]
Todorov I, Nair I, Ferreri K, Rawson J, Kuroda A, Pascual M, Omori K, Valiente L, Orr C, Al-Abdullah I, Riggs A, Kandeel F, Mullen Y. Multipotent progenitor cells isolated from adult human pancreatic tissue. Transplant Proc. 2005 Oct;37(8):3420-1. [PubMed Abstract]
Wang W, Upshaw L, Strong DM, Robertson RP, Reems J: Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets. J.Endocrinol. 185:445-455, 2005 [PubMed Abstract]
Witkowski P, Liu Z, Guo Q, Poumian-Ruiz E, Cernea S, Herold K, Hardy MA: Two-layer method in short-term pancreas preservation for successful islet isolation. Transplant Proc. 37:3398-3401, 2005 [PubMed Abstract]
Yang Z, Chen M, Ellett JD, Carter JD, Brayman KL, Nadler JL. Inflammatory blockade improves human pancreatic islet function and viability. Am J Transplant 2005 Mar;5(3):475-83. [PubMed Abstract]
Zheng Q, Dai H, Merritt ME, Malloy C, Pan CY, Li W-H: A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications. J. Am. Chem. Soc., 2005, 127 (46), 16178-16188 27 October 2005
2004 (24)
Abdelli S, Ansite J, Roduit R, Borsello T, Matsumoto I, Sawada T, Allaman-Pillet N, Henry H, Beckmann JS, Hering BJ, Bonny C: Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 53:2815-2823, 2004 [PubMed Abstract]
Brissova M, Fowler M, Wiebe P, Shostak A, Shiota M, Radhika A, Lin PC, Gannon M, Powers AC. Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes 2004 May;53(5):1318-25 [PubMed Abstract]
Cheng K, Fraga D, Zhang C, Kotb M, Gaber AO, Guntaka RV, Mahato RI: Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther. 11:1105-1116, 2004 [PubMed Abstract]
Cure P, Pileggi A, Froud T, Norris PM, Baidal DA, Cornejo A, Hafiz MM, Ponte G, Poggioli R, Yu J, Saab A, Selvaggi G, Ricordi C, Alejandro R: Alterations of the female reproductive system in recipients of islet grafts. Transplantation 78:1576-1581, 2004 [PubMed Abstract]
Fenjves ES, Ochoa MS, Gay-Rabinstein C, Ricordi C, Curran MA: Retrovirally transferred genes inhibit apoptosis in an insulin-secreting cell line: implications for islet transplantation. Cell Transplant 2004; 13(5):489-96. [PubMed Abstract]
Gaber AO, Fraga D, Kotb M, Lo A, Sabek O, Latif K: Human islet graft function in NOD-SCID mice predicts clinical response in islet transplant recipients. Transplant Proc. 36:1108-1110, 2004 [PubMed Abstract]
Hafiz MM, Poggioli R, Caulfield A, Messinger S, Geiger MC, Baidal DA, Froud T, Ferreira JV, Tzakis AG, Ricordi C, Alejandro R: Cytomegalovirus prevalence and transmission after islet allograft transplant in patients with type 1 diabetes mellitus. Am.J.Transplant 4:1697-1702, 2004 [PubMed Abstract]
Han D, Xu X, Baidal D, Leith J, Ricordi C, Alejandro R, Kenyon NS: Assessment of cytotoxic lymphocyte gene expression in the peripheral blood of human islet allograft recipients: elevation precedes clinical evidence of rejection. Diabetes 53:2281-2290, 2004 [PubMed Abstract]
Holz GG. Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 2004 Jan;53(1):5-13 [PubMed Abstract]
Hope KM, Tran POT, Zhou H, Oseid E, LeRoy E, Robertson RP. Regulation of Alpha Cell Function by the Beta Cell in Isolated Human and Rat Islets Deprived of Glucose: the "Switch-off" Hypothesis. Diabetes 53:1488-1495, 2004. PMID: 15161753
Kaido T, Yebra M, Cirulli V, Montgomery AM: Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1. J Biol Chem 2004 Dec 17;279(51):53762-9. Epub 2004 Oct 12 6. [PubMed Abstract]
Kaido T, Perez B, Yebra M, Hill J, Cirulli V, Hayek A, Montgomery AM: Alphav-integrin utilization in human beta-cell adhesion, spreading, and motility. J Biol Chem 2004 Apr 23;279(17):17731-7. Epub 2004 Feb 6. [PubMed Abstract]
Klein D, Ribeiro MM, Mendoza V, Jayaraman S, Kenyon NS, Pileggi A, Molano RD, Inverardi L, Ricordi C, Pastori RL: Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets.  Biochem.Biophys.Res.Commun. 323:473-478, 2004 [PubMed Abstract]
Maffei A, Liu Z, Witkowski P, Moschella F, Del Pozzo G, Liu E, Herold K, Winchester RJ, Hardy MA, Harris PE: Identification of Tissue Restricted Transcripts in Human Islets. Endocrinology 2004 [PubMed Abstract]
Matsumoto I, Sawada T, Nakano M, Sakai T, Liu B, Ansite JD, Zhang HJ, Kandaswamy R, Sutherland DE, Hering BJ: Improvement in Islet Yield from Obese Donors for Human Islet Transplants. Transplantation 78:880-885, 2004 [PubMed Abstract]
Matsumoto S, Tanaka K, Strong DM, Reems JA: Efficacy of Human Islet Isolation From the Tail Section of the Pancreas for the Possibility of Living Donor Islet Transplantation. Transplantation 78:839-843, 2004 [PubMed Abstract]
Narang AS, Cheng K, Henry J, Zhang C, Sabek O, Fraga D, Kotb M, Gaber AO, Mahato RI: Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets. Pharm.Res. 21:15-25, 2004 [PubMed Abstract]
Pileggi A, Fenjves ES, Klein D, Ricordi C, Pastori RL: Protecting pancreatic beta-cells. IUBMB.Life 56:387-394, 2004 [PubMed Abstract]
Ritzel RA, Hansen JB, Veldhuis JD, Butler PC. Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab 2004 Feb;89(2):795-805 [PubMed Abstract]
Rush BT, Fraga DW, Kotb MY, Sabek OM, Lo A, Gaber LW, Halim AB, Gaber AO: Preservation of human pancreatic islet in vivo function after 6-month culture in serum-free media. Transplantation 77:1147-1154, 2004 [PubMed Abstract]
Sweet IR, Cook DL, DeJulio E, Wallen AR, Khalil G, Callis J, Reems J: Regulation of ATP/ADP in Pancreatic Islets. Diabetes 53:401-409, 2004 [PubMed Abstract]
Virostko J, Fowler M, Chen Z, Powers AC, Jansen ED: Factors influencing quantification of in vivo bioluminescence imaging: application to assessment of pancreatic islet transplants. Molecular Imaging 4:1-10, 2004 [PubMed Abstract]
Wiseman AC, Gill RG: Current status of clinical islet transplantation: advances and obstacles. Curr Opin Endocrinol Diabetes. 11:98-103, 2004 [No Abstract Available]
Zhang G, Matsumoto S, Hyon SH, Qualley SA, Upshaw L, Strong DM, Reems JA: Polyphenol, an Extract of Green Tea, Increases Culture Recovery Rates of Isolated Islets From Nonhuman Primate Pancreata and Marginal Grade Human Pancreata. Cell Transplantation 13:145-152 , 2004 [PubMed Abstract]
2003 (12)
Baidal DA, Froud T, Ferreira JV, Khan A, Alejandro R, Ricordi C: The bag method for islet cell infusion. Cell Transplant 12:809-813, 2003 [PubMed Abstract]
Desai NM, Goss JA, Deng S, Wolf BA, Markmann E, Palanjian M, Shock AP, Feliciano S, Brunicardi FC, Barker CF, Naji A, Markmann JF: Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity? Transplantation 76:1623-1625, 2003 [PubMed Abstract]
Kandeel, Fouad; Smith, Craig V.; Todorov, Ivan; Mullen, Yoko: Advances in Islet Cell Biology: From Stem Cell Differentiation to Clinical Transplantation: Conference Report. Pancreas. 27(3):e63-e78, October 2003. [PubMed Abstract]
Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, Schwede F, Genieser HG, Holz GG. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem 2003;278(10):8279-85. [PubMed Abstract]
Mahato RI, Henry J, Narang AS, Sabek O, Fraga D, Kotb M, Gaber AO: Cationic lipid and polymer-based gene delivery to human pancreatic islets. Mol.Ther. 7:89-100, 2003 [PubMed Abstract]
Markmann JF, Deng S, Huang X, Desai NM, Velidedeoglu EH, Lui C, Frank A, Markmann E, Palanjian M, Brayman K, Wolf B, Bell E, Vitamaniuk M, Doliba N, Matschinsky F, Barker CF, Naji A: Insulin independence following isolated islet transplantation and single islet infusions. Ann.Surg. 237:741-750, 2003 [PubMed Abstract]
Markmann JF, Rosen M, Siegelman ES, Soulen MC, Deng S, Barker CF, Naji A: Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival? Diabetes 52:1591-1594, 2003 [PubMed Abstract]
Ricordi C: Islet transplantation: a brave new world. Diabetes 52:1595-1603, 2003 [PubMed Abstract]
Ritzel RA, Veldhuis JD, Butler PC: Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass; dose-response relationships. J Clin Endocrinol Metab 2003 Feb. 88(2):724-747. [PubMed Abstract]
Ritzel RA, Butler PC: Replication increases beta cell vulnerability to human islet amyloid polypeptide induced apoptosis. Diabetes 2003. 52:1701-1708. [PubMed Abstract]
Robertson RP, Kendall DM: Islet transplantation 2003: questions about its future. Curr Opin Endocrinol Diabetes 10:128-132, 2003.
Song SH, Rhodes CJ, Veldhuis JD, Butler PC: Diazoxide attenuates glucose-induced defects in first phase insulin release and pulsatile insulin secretion in human islets. Endocrinology 2003 Aug. 144(8):3399-3405. [PubMed Abstract]
2002 (9)
Hering BJ, Matsumoto I, Sawada T, Nakano M, Sakai T, Kandaswamy R, Sutherland DE: Impact of two-layer pancreas preservation on islet isolation and transplantation. Transplantation 74:1813-1816, 2002 [PubMed Abstract]
Knazek RA: The human pancreatic islet cell resource consortium. Diabetes Technol.Ther. 4:551-552, 2002 [PubMed Abstract]
Matsumoto S, Qualley SA, Goel S, Hagman DK, Sweet IR, Poitout V, Strong M, Robertson RP, Reems JA: Effect of the two-layer [University of Wisconsin Solution (UW) / Perfluorochemical (PFC) Plus 02] method of pancreas preservation on human islet isolation as assessed by the Edmonton isolation protocol1 Transplantation 74(10):1414-9,2002. PMID: 12451242 [PubMed Abstract]
Paty B, Ryan E, Shapiro AM, Lakey J, Robertson RP: Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 51(12):3428-34, 2002. [PubMed Abstract]
Robertson RP: Intrahepatically transplanted islets: Strangers in a strange land. J Clin Endocrinol Metab 87(12):5416-7, 2002. Full Text
Song SH, Kjems L, Ritzel R, McIntyre SM, Johnson ML, Veldhuis JD, Butler PC: Pulsatile insulin secretion by human pancreatic islets. J Clin Endocrinol Metab 2002 Jan;87(1):213-21. [PubMed Abstract]
Sweet IR, Khalil G, Wallen AR, Steedman M, Schenkman KA, Reems JA, Kahn SE, Callis JB: Continuous measurement of oxygen consumption by pancreatic islets. Diabetes Technol.Ther.4:661-672, 2002 [PubMed Abstract]
Tanaka Y, Tran PO, Harmon J, Robertson RP: A role for glutathione peroxidase in protecting pancreatic B cells against oxidative stress in a model of glucose toxicity. Proc Natl Acad Sci USA 99(19):12363-8, 2002. PMID: 12218186 [PubMed Abstract]
Wang DA, Narang AS, Kotb M, Gaber AO, Miller DD, Kim SW, Mahato RI: Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery. Biomacromolecules. 3:1197-1207, 2002 [PubMed Abstract]
Publications by the IIDP Coordinating Center (13)
Olack BJ, Alexander M, Swanson CJ, Kilburn J, Corrales N, Flores A, Heng J, Arulmoli J, Omori K, Chlebeck PJ, Zitur L, Salgado M, Lakey JRT, Niland JC. Optimal Time to Ship Human Islets Post Tissue Culture to Maximize Islet Recovery. Cell Transplant, 2020 Jan-Dec, 29: 1–10.
Olack BJ, Linetsky E, Niland JC. Human islet distribution during COVID-19 pandemic: the impact on diabetes research. CellR4 Repair Replace Regen Reprogram, Commentary, 2020 Oct, (8): e2955.
Scott A, Olack B, Rouch JD, Khalil HA, Kokubun BA, Lei NY, Wang J, Solorzano S, Lewis M, Dunn JCY, Stelzner MG, Niland JC, Martin MG. Comparison of Surgical and Cadaveric Intestine as a Source of Crypt Culture in Humans. Cell Transplant, 2020 Sept, 29: 1-12. PMID: 32907378
Olack BJ, Kilburn J, Chuang J-NJ, Cravens J, Niland JC. 122-OR: Profile of Type 2 Diabetes (T2D) Donors in the Integrated Islet Distribution Program (IIDP). Diabetes, Oral Presentation, 2020 Jun, 69(Supplement 1): 122-OR.
Brissova M, Niland JC, Cravens J, Olack B, Sowinski J, Evans-Molina C. The Integrated Islet Distribution Program answers the call for improved human islet phenotyping and reporting of human islet characteristics in research articles. Simultaneously published as a Letter to the Editor | MAY 15 2019 in Diabetes, 2019 May: 68 (7). Diabetologia , 2019 Jul: 62(7): 1312–1314
Kaddis JS, Hanson MS, Cravens J, Qian D, Olack B, Antler M, Papas KK, Iglesias I, Barbaro B, Fernandez L, Powers AC, Niland JC. Standardized transportation of human islets: an islet cell resource center study of more than 2,000 shipments. Cell Transplant, 2013 Aug, 22(7): 1101-11. PMCID: 3745279.
Niland JC, Stiller T, Cravens J, Sowinski J, Kaddis J, Qian D. Effectiveness of a web-based automated cell distribution system. Cell Transplant, 2010 May, 19(9): 1133-42. PMCID: 3242440.
Kaddis JS, Danobeitia JS, Niland JC, Stiller T, Fernandez LA. Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes. Am J Transplant, 2010 Mar, 10(3): 646-56. PMCID: 2860018.
Kissler HJ, Niland JC, Olack B, Ricordi C, Hering BJ, Naji A, Kandeel F, Oberholzer J, Fernandez L, Contreras J, Stiller T, Sowinski J, Kaufman DB. Validation of methodologies for quantifying isolated human islets: an Islet Cell Resources study. Clin Transplant, 2010 Mar, 24(2): 236-42. PMCID: 3166241.
Kaddis JS, Olack BJ, Sowinski J, Cravens J, Contreras JL, Niland JC. Human pancreatic islets and diabetes research. JAMA, 2009 Apr, 301(15): 1580-7. PMCID: 3763818.
Qian D, Kaddis J, Niland JC. A matching algorithm for the distribution of human pancreatic islets. Comput Stat Data Anal, 2007 Aug, 51(12): 5494-506. PMCID: 3243971.
Papas KK, Colton CK, Nelson RA, Rozak PR, Avgoustiniatos ES, Scott WE, 3rd, Wildey GM, Pisania A, Weir GC, Hering BJ. Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant, 2007 Mar, 7(3): 707-13. PMCID: 2857994.
Published SOPs by the IIDP Coordinating Center (12)
Integrated Islet Distribution Program: Collection, Broadcast, Packaging and Shipping of Non-Islet Biomaterials. protocols.io, 2023 Jun 07.
Integrated Islet Distribution Program: Determining IIDP Minimal Donor Criteria V.3. protocols.io, 2023 Apr 19.
Integrated Islet Distribution Program: Potency Test: Glucose Stimulated Insulin Release Assay V.3. protocols.io, 2021 May 13.
Integrated Islet Distribution Program: Collection, Packaging and Cold Shipping of Fresh Non-Islet Pancreatic (Acinar) Tissue. protocols.io, 2020 Sep 23, V.1.
Integrated Islet Distribution Program: Qualitative & Quantitative Assessment of Human Islets for Distribution Using Dithizone (DTZ) V.4. protocols.io, 2020 Sep 9.
Integrated Islet Distribution Program: Flash Freezing Unclaimed Islets V.1. protocols.io, 2020 Jul 15.
Integrated Islet Distribution Program: Packaging and Shipping of Flash Frozen Non-Islet Pancreatic (Acinar)Tissue. protocols.io, 2020 Jul 15.
Integrated Islet Distribution Program: Islet Culture and Preparation for Cold Shipping V.1. protocols.io, 2020 Jun 18.
Integrated Islet Distribution Program: Sentinel Flask Preparation for Cold Shipping Protocol of Human Islets V.2. protocols.io, 2020 Jun 11.
Integrated Islet Distribution Program: Packaging and Cold Shipping of Human Islets V.2. protocols.io, 2020 Jun 11.
Integrated Islet Distribution Program: Viability Estimation of Islets for Distribution Using Inclusion and Exclusion Fluorescent Dyes (FDA/PI) V.2. protocols.io, 2020 Jun 11.
Integrated Islet Distribution Program: Attachment 1: Preparation of Fluorescein Diacetate and Propidium Iodide Stock Solutions (FDA/PI). protocols.io, 2019 Dec 18.
Publications of Interest (17)
Ghislain J, Poitout V. Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges. Nat Rev Endocrinol, 2021 Mar Review, 17(3): 162-75.
Atkinson MA, Campbell-Thompson M, Kusmartseva I, Kaestner KH. Organisation of the human pancreas in health and in diabetes. Diabetologia, 2020 Oct, 63(10): 1966-73. PMCID: PMC7565096.
Network OPTN. OPTN Policies Effective as of April 3 2020 [Emergency COVID-19 Policy Actions], 2020 Apr.
Witkowski P, Philipson L, Kaufman DB, Ratner L, Abouljoud MS, Bellin M, Buse J, Kandeel F, Stock P, Mulligan D, Markmann JF, Kozlowski T, Andreoni K, Alejandro R, Baidal D, Hardy MA, Wickrema A, Mirmira RG, Fung J, Becker Y, Josephson MA, Bachul PJ, Pyda JS, Charlton M, Millis JM, Gaglia J, Stratta RJ, Fridell JA, Niederhaus S, Forbes RC, Jayant K, Robertson RP, Odorico J, Levy M, Harland R, Abrams PL, Olaitan OK, Kandaswamy R, Wellen J, Japour AJ, Desai CS, Naziruddin B, Balamurugan AN, Barth RN, Ricordi C. The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The "ISLETS FOR US" Collaborative. Am J Transplant, 2020 Nov 29
Kaestner KH, Powers AC, Naji A, Consortium H, Atkinson MA. NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP). Diabetes, 2019 Jul, 68(7): 1394-402. PMCID: 6609987
Hart NJ, Powers AC. Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions. Diabetologia, 2019 Feb, 62(2): 212-22
Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG, Jr., Marshall SM. A call for improved reporting of human islet characteristics in research articles. Simultaneously published as an Editorial in Diabetologia, 2019 Feb, 62(2): 209-11. Diabetes, 2019 Feb, 68(2): 239-40
Scharp DW, Arulmoli J, Morgan K, Sunshine H, Hao E. Advances in Human Islet Processing: Manufacturing Steps to Achieve Predictable Islet Outcomes from Research Pancreases. OBM Transplantation, 2019 Feb, 3(1): 1-7
Kusmartseva I, Beery M, Philips T, Selman S, Jadhav P, Wasserfall C, Muller A, Pugliese A, Longmate JA, Schatz DA, Atkinson MA, Kaddis JS. Hospital time prior to death and pancreas histopathology: implications for future studies. Diabetologia, 2018 Apr, 61(4): 954-8. PMCID: PMC5844815.
Bandrowski A, Brush M, Grethe JS, Haendel MA, Kennedy DN, Hill S, Hof PR, Martone ME, Pols M, Tan SS, Washington N, Zudilova-Seinstra E, Vasilevsky N, Initiative RRI. The Resource Identification Initiative: A Cultural Shift in Publishing. Neuroinformatics, 2016 Apr, 14(2): 169-82. PMCID: 5072392.
Ricordi C, Goldstein JS, Balamurugan AN, Szot GL, Kin T, Liu C, Czarniecki CW, Barbaro B, Bridges ND, Cano J, Clarke WR, Eggerman TL, Hunsicker LG, Kaufman DB, Khan A, Lafontant DE, Linetsky E, Luo X, Markmann JF, Naji A, Korsgren O, Oberholzer J, Turgeon NA, Brandhorst D, Chen X, Friberg AS, Lei J, Wang LJ, Wilhelm JJ, Willits J, Zhang X, Hering BJ, Posselt AM, Stock PG, Shapiro AM, Chen X. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes, 2016 Nov, 65(11): 3418-28. PMCID: 5079635. Erratum. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418-3428. Diabetes, 2017 Sep, 66(9): 2531. PMCID: 5566298
Nano R, Bosco D, Kerr-Conte JA, Karlsson M, Charvier S, Melzi R, Ezzouaoui R, Mercalli A, Hwa A, Pattou F, Korsgren O, Berney T, Piemonti L. Human islet distribution programme for basic research: activity over the last 5 years. Diabetologia, 2015 May, 58(5): 1138-40.
Collins FS, Tabak LA. Policy: NIH plans to enhance reproducibility. Nature, 2014 Jan, 505(7485): 612-3. PMCID: 4058759.
OPTN (PHS). 2013 PHS Guideline for Reducing Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Transmission through Organ Transplantation1 Behavioral Risk Factors for Recent HIV, HBV, or HCV Infection. Organ Procurement and Transplantation Network, 2013 Nov.
Piemonti L, Pileggi A. 25 Years of the Ricordi Automated Method for Islet Isolation. CellR4 Repair Replace Regen Reprogram, 2013 Jan, 1(1). PMCID: 6267808
Avgoustiniatos ES, Scott WE, 3rd, Suszynski TM, Schuurman HJ, Nelson RA, Rozak PR, Mueller KR, Balamurugan AN, Ansite JD, Fraga DW, Friberg AS, Wildey GM, Tanaka T, Lyons CA, Sutherland DE, Hering BJ, Papas KK. Supplements in human islet culture: human serum albumin is inferior to fetal bovine serum. Cell Transplant, 2012 Aug, 21(12): 2805-14.