In the GPCR world, the notion of biased signalling
or functional selectivity posits that only a subset of signalling
events downstream of a given receptor are therapeutically relevant whereas some cause adverse effects and should be avoided. In the last few years, this notion has translated into the development of signalling
platforms to capture bias in cellulo
and the tools to capture and quantify bias. This symposium would focus on the movement of such platforms into tissue models, successes and failures of biased ligand development clinically and the expansion of the concept of biased signalling
into other types of receptors. Click here
to go to the website for more information.